The Zebrafish Model in Neurological Research: Implications for Clinical Practice | ||
| Egyptian Journal of Aquatic Biology and Fisheries | ||
| Volume 29, Issue 5, September and October 2025, Pages 2643-2671 PDF (631.67 K) | ||
| Document Type: Review articles | ||
| DOI: 10.21608/ejabf.2025.427354.6657 | ||
| Author | ||
| Dubey et al. | ||
| Abstract | ||
| Despite their striking similarities to humans in terms of genetics, anatomy, and physiology, zebrafish (Danio rerio) have emerged as a promising alternative model for studies involving the nervous system. Their well-defined neural system, high genetic similarity, and clear embryogenesis make them ideal for studying neurological problems in detail. Neurodevelopmental and neurodegenerative disorders, such as epilepsy, Parkinson's, and Alzheimer's, are best studied using these models because of their practical benefits, which include fast reproduction, minimal maintenance cost, and compatibility with high-throughput screening. They are genetically tractable, which enables accurate modeling of human neuropathology, and they have strong behavioral tests that provide measurable indicators of motor, cognitive, and emotional capabilities. The use of live imaging methods in real-time brain analysis has been greatly enhanced by recent advancements, such as calcium-based neuronal activity monitoring. This review discusses the constraints of translating zebrafish research to mammalian systems, illustrates the advantages of zebrafish as a neurobiological model, and highlights important research results. Taking everything into account, zebrafish serve as an excellent model for studying neurological processes and expediting the development of customized treatments. | ||
| Keywords | ||
| Zebra fish; Neurodevelopmental; Alternative model; Anatomy; Physiology | ||
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