Evaluation of Antimicrobial Activity of Ceftobiprole against Methicillin-Resistant Staphylococcus Aureus (MRSA) In Surgical Site Infections at Cairo University Hospitals | ||
| Egyptian Journal of Medical Microbiology | ||
| Articles in Press, Accepted Manuscript, Available Online from 01 April 2026 | ||
| Document Type: New and original researches in the field of Microbiology. | ||
| DOI: 10.21608/ejmm.2025.426820.1891 | ||
| Authors | ||
| Moushira H. Ezz El Arab1; Monika N. Anwar2; Amira M. Abbas3; Amal Sayed4; Ahmed Khedr5; Mennat-Allah H. Salama* 2 | ||
| 1Clinical and Chemical Pathology, Kasralainy Faculty of Medicine, Cairo University, Cairo, Egypt. | ||
| 2Clinical and Chemical Pathology department, Kasr Al Ainy Faculty of Medicine, Cairo University, Cairo, Egypt. | ||
| 3Clinical and Chemical Pathology Department, Kasr Al Ainy Faculty of Medicine, Cairo University, Cairo, Egypt | ||
| 4Department of Clinical and Chemical Pathology, Kasr Al Ainy, Faculty of Medicine, Cairo University, Cairo, Egypt. | ||
| 5Orthopedic Surgery department, Kasr Al Ainy Faculty of Medicine, Cairo University, Cairo, Egypt. | ||
| Abstract | ||
| Background: Surgical Site Infections (SSIs) are the third most commonly reported nosocomial infections after intensive care unit infections and urinary tract infections in a hospital setup approaching 14–16% of all nosocomial infections and 2.5% to as high as 41.9% of nosocomial infections in surgical patients. Staphylococcus aureus (S. aureus) infections, especially methicillin-resistant S. aureus (MRSA) infections, when serious, are associated with high morbidity and mortality. For the treatment of MRSA, only a few antibiotics have been approved. The bactericidal activity of the antibiotic Ceftobiprole against MRSA sets it apart from other Cephalosporins (with the exception of Ceftaroline). It’s efficacy against MRSA is due to a successful inhibitory interaction with the extended narrow groove of the Penicillin binding protein 2a (PBP2a) active site coded by mec genes, favoring its acylation, inhibiting cell growth, and ultimately, leading to bacterial cell death. Objective: This work aims to evaluate the antimicrobial activity of ceftobiprole against MRSA strains isolated from surgical site infections in Cairo university hospitals. Methodology: This is a cross-sectional study conducted on sixty-four MRSA isolates isolated from SSIs to detect the sensitivity of MRSA to ceftobiprole using Minimal inhibitory concentration (MIC) by Epsilometer test (Etest). Results Out of the 64 MRSA isolates tested, around 10.9% of isolates showed resistance to ceftobiprole while 89.1% were susceptible. Conclusion: Ceftobiprole showed excellent antibacterial activity against MRSA isolates. Ceftobiprole seems to be a very promising alternative against MRSA infections. | ||
| Keywords | ||
| Ceftobiprole; Epsilometer test; MIC; MRSA | ||
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