Pattern Of Bacterial and Fungal Bloodstream Infections Caused by Multidrug Resistant Organisms in Patients with Septicemia Admitted at Surgical Intensive Care Unit | ||
| Egyptian Journal of Medical Microbiology | ||
| Articles in Press, Accepted Manuscript, Available Online from 01 April 2026 | ||
| Document Type: New and original researches in the field of Microbiology. | ||
| DOI: 10.21608/ejmm.2025.427623.1897 | ||
| Authors | ||
| Madonna S. Zaki* 1; Ahmed Sadek2; Tarek Hemaida3; Mohamed M. Amin1 | ||
| 1Department of Medical Microbiology & Immunology, Faculty of Medicine, Aswan University, Aswan, Egypt | ||
| 2Department of Medical Microbiology & Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt | ||
| 3Department of Surgical Intensive Care and Pain Management, Faculty of Medicine, Aswan University, Aswan, Egypt. | ||
| Abstract | ||
| Background: Bloodstream infections (BSI) are widely recognized as one of the most critical infections, strongly linked to high morbidity and mortality, particularly among patients in intensive care units (ICUs). It causes a significant burden due to its consequences and complications. Objectives: This study investigated the prevalence of multidrug-resistant bacterial and fungal strains isolated from blood samples of the patients admitted to (ICU) and sought to update the hospital antibiogram accordingly to minimize long-term antimicrobial resistance. Methodology: blood cultures collected from 100 patients, and analyzed by (BACTEC 9050), after the diagnosis of sepsis is confirmed according to The Sequential Organ Failure Assessment (SOFA) score. To confirm the identification of the isolated strains and the analysis of the resistance patterns, Antibiotics were performed using VITEK 2 _ compact 15 system and VITEK 2 ID/AST cards. Results: Blood cultures demonstrated that 8% of 100 clinically septic cases showed no microbial growth, while 92% yielded identifiable organisms, predominantly Gram-negative bacteria (54%) and Gram-positive bacteria (38%), followed by anaerobes (4%) and Candida species (4%). Methicillin-resistant Staphylococcus aureus (MRSA) (22%) and Klebsiella pneumoniae (19%) were the most frequently isolated pathogens, followed by Escherichia coli (E. coli) (16%) and Pseudomonas Spp. (9%). Less common isolates included Coagulase-negative staphylococci (CoNS) (6%), and Clostridium. Regarding the fate and outcome findings, the growth group had a significantly longer hospital stay (16 (10 - 25.5) vs. 6.5 (4.5 - 20.5) days, p-value= 0.043). SOFA score and mortality rates slightly increase in growth group but did not show significant variation between the groups as (p-value= 0.202 & 0.204 respectively). Conclusions: Treatment failures are increasingly common due to rising resistance among both Gram-positive and Gram-negative bacteria, contributing to higher mortality, prolonged ICU stays, and increased healthcare costs. | ||
| Keywords | ||
| Multi drug resistant organisms; Blood stream infections; SOFA score; Antibiotic resistance; ICU | ||
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