Antibacterial Activity of Syzygium aromaticum (Clove) Against MDR Bacteria Isolated from Diabetic Foot Ulcer and Wound healing | ||
| Mansoura Journal of Biology | ||
| Volume 53, Issue 4, December 2021, Pages 42-54 PDF (1.25 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjb.2021.460006 | ||
| Authors | ||
| Rewaa Ali* 1; G El-Didamony2; G Enan2; G Abdel-Fattah 1 | ||
| 1Department of Botany and Microbiology, Faculty of Science, Mansoura University, Mansoura, Egypt | ||
| 2Department of Botany and Microbiology, Faculty of Science, Zagazig University, Zagazig, Egypt. | ||
| Abstract | ||
| Diabetes mellitus is a chronic lifelong disorder that distinguishes oneself by chronic hyperglycemia and caused damage to organs. Bad control of diabetes leads to skin infections and non-healing foot ulcers which are common in clinical practice. The access to the hospital and mutilation will increase and conversely result in long-term economic, physical, social, and mental disability to the patient. This study is designed to isolate and determine the susceptibility of isolated bacteria to different antibiotics. Drug-resistant bacteria were selected and identified by vitek system 2 and MIC of these isolates were determined. Results revealed that 83 isolates were isolated from 47 patients with diabetic foot infection polymicrobial growth cultures were found in all-patients. Gram negative bacteria showed a high percentage of resistance to tested antibiotics. Proteus mirabilis isolate LC587231 record the highest index of antibiotics resistance (0.83). This isolate inhibited by ethanolic extracts of clove at MIC = 12.89 ug/ml and topical application of hydrogel containing clove extract improved wound size, wound index of infected diabetic wound model. | ||
| Keywords | ||
| MDR-Proteus mirabilis; Syzygium aromaticum; Diabetic foot ulcer; Wound Healing | ||
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