Study of Biochemical Markers as Risk Factor for Leukemia in Egyptian Children | ||
| Mansoura Journal of Biology | ||
| Volume 52, Issue 3, October 2021, Pages 53-60 PDF (547.05 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjb.2021.460023 | ||
| Authors | ||
| Safaa B Elmasry* 1; Hamdy I Zaied2; Afaf M Elsaeed3; Wafaa M Elkholy1 | ||
| 1Zoology Department, Faculty of Science, Mansoura University, Mansoura ,Egypt | ||
| 2Professor of Animal physiology and Ecology ,Zoology department-Faculty of Sciene Mansoura University, Mansoura ,Egypt. | ||
| 3Consultant of Biochemistry and Molecular Biology- Children Hospital Mansoura University,Mansoura ,Egypt. | ||
| Abstract | ||
| The balance of reactive species( ROS ) effect is occured by the action of enzymatic antioxidants and non-enzymatic antioxidants. ROS-induced apoptosis is used by the human body to eliminate precancerous and cancerous cells. This study aimed to assess the OS by estimation of malondialdehyde (MDA) , antioxidants as superoxide dismutase (SOD), catalase (CAT), glutathione(GSH) and apoptosis markers as protein (P53) and b-cell lymphoma 2 (BCL2) in patients with ALL of children.This study produced 50 children diagnosed acute lymphoplastic leukemia (ALL) (mean age, 5.8 years) compared to 50 healthy controls (mean age, 5.6 years). Significant decreases obtained in serum P53 (pg/ml) and B-CL2 (U/ml), MDA (nmol/ml) and GSH (nmol/mg) with ALL comparing with the normal control group. But, significant increases were found in serum SOD(U/ml) and CAT(U/L) with ALL compared to the control group (p<0.001). .Conclusion: A strong association between apoptosis (P53 and BCL-2) ,oxidative stress(MDA) and (SOD, CAT, GSH) antioxidants with acute lymphoplastic leukemia . | ||
| Keywords | ||
| Oxidative stress(OS); antioxidants; apoptosis | ||
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