Assessment of Platelet Indices in Children With Different Subtypes of Primary Immune Thrombocytopenia On Different Treatment Modalities | ||
| Minia Journal of Medical Research | ||
| Articles in Press, Accepted Manuscript, Available Online from 19 October 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2025.413007.2077 | ||
| Authors | ||
| Asmaa Hosni Abdel Hafez* 1; Suzan Mohamed Aly Omar2; Ayman Ahmed Mahmoud Abd Rabou3; Sara Said Abdelazim4; Zamzam Hassan Mohamed5 | ||
| 1Pediatric department, Faculity of medicine, Minia university, El Minia | ||
| 2Department of Pediatrics, Faculty of Medicine, Minia University, El-Minia, Egypt | ||
| 3Clinical pathology department, Faculty of medicine, Minia Univerisity | ||
| 4pediatric department Faculty of Medicine, Minia University, Egypt | ||
| 5Pediatrics Faculty of Medicine, Minia University | ||
| Abstract | ||
| Background: ITP is an acquired autoimmune disease with a variety of etiologies, symptoms of bleeding, , therapy response, and longevity. Platelet parameter is a simple examination which can reflect the proliferation kinetics of platelets valuable to diagnosis and follow-up. This study aimed to assess platelet indices in children with ITP receiving different treatment modalities. Methods: The study was carried out on 60 ITP children and 60 children as control aged between 2-18 years old. All received first or second line drugs. Basic medical history data were collected. Initial and follow up Platelet count, MPV, PDW and PCT were assessed. Results: We found platelet count lower in newly diagnosed children than other groups. Chronic cases showed more grade 3 initial bleeding score than other groups . PDW was higher in newly diagnosed cases than other groups. 87.9% newly diagnosed, 9.1% and 3% chronic cases needed first line therapy while 0% newly diagnosed, 25.9%persistent cases and 74.1% chronic cases needed second line therapies. All treatment modalities showed success in improving platelet count and bleeding score. Platelet count was significantly higher and PDW was significantly lower after first line drugs more than second line drugs. Platelet count was the most specific parameter predicting failure of response to first-line therapy while PCT and PDW were the most specific parameters predicting failure of response to second -line therapy. Conclusion: platelet indices change according to different types of primary ITP in children and according to different treatment modalities and can predict response to therapy. | ||
| Keywords | ||
| bleeding score; patients; immune thrombocytopenic; platelet indices; response | ||
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