Bromelain diminishes renal consequences induced by gamma irradiation via suppressing ACE/Ang-II/aldosterone pathway in rats | ||
| Egyptian Journal of Radiation Sciences and Applications | ||
| Articles in Press, Accepted Manuscript, Available Online from 19 October 2025 PDF (1.81 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejrsa.2025.387015.1186 | ||
| Authors | ||
| Shereen Mohamed Galal* 1; Heba Hosney Mansour2; shereen mohamed El Kiki3 | ||
| 1Health Radiation Research Department, National Center for Radiation Research and Technology, Atomic energy authority | ||
| 2Health Radiation Research Department, National Center for Radiation Research and Technology, | ||
| 3health radiation research department, national center for radiation research and technology, atomic energy authority | ||
| Abstract | ||
| Radiation causes renal damage by enhancing the renin-angiotensin-aldosterone system's (RAAS) activation. This work aimed to evaluate the role of bromelain, an angiotensin-converting enzyme inhibitor (ACEI) in hindering the inflammatory and fibrotic impact of radiation via suppressing this pathway. Rats were subjected to a single dosage of 7.5 Gy then administered bromelain (30 mg/kg) orally for 14 days after one hour of irradiation. Gamma radiation caused a considerable increase in (RAAS) indices such as angiotensin II (AngII), aldosterone and angiotensin-converting enzyme (ACE) protein expression, in along with renal function: urea, creatinine and blood urea nitrogen with significant disturbance in oxidative stress markers: malondialdehyde (MDA), protein carbonyl (PCO), reduced glutathione (GSH), total thiol (tSH) and superoxide dismutase (SOD) in renal tissue homogenate. In addition, there was a notable increase in the renal inflammatory mediator's levels: tumor necrosis factor-α (TNF-α), nuclear factor kappa B (NF-κB) and interleukin-1β (IL-1β) alongside serum profibrotic markers: hyaluronic acid (HA), laminin (LN), type III procollagen (PCIII) and renal hydroxyproline (HYP) levels. Bromelain treatment dramatically improves the previously described parameters and modifies the radiation-induced renal histopathological damage in retaliation to the suppression of ACE, Ang II and aldosterone expressions. Conclusions: Bromelain hinders radiation-induced inflammatory, fibrotic and oxidative stress response via remodelling the RAAS pathway in rats | ||
| Keywords | ||
| Bromelain; ACE; radiation; Angiotensin II; aldosterone | ||
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