Bromelain diminishes renal consequences induced by gamma irradiation via suppressing ACE/Ang-II/aldosterone pathway in rats
Galal, S., Mansour, H., El Kiki, S. (2025). Bromelain diminishes renal consequences induced by gamma irradiation via suppressing ACE/Ang-II/aldosterone pathway in rats. EKB Journal Management System, 38(1), 75-89. doi: 10.21608/ejrsa.2025.387015.1186
Shereen Mohamed Galal; Heba Hosney Mansour; shereen mohamed El Kiki. "Bromelain diminishes renal consequences induced by gamma irradiation via suppressing ACE/Ang-II/aldosterone pathway in rats". EKB Journal Management System, 38, 1, 2025, 75-89. doi: 10.21608/ejrsa.2025.387015.1186
Galal, S., Mansour, H., El Kiki, S. (2025). 'Bromelain diminishes renal consequences induced by gamma irradiation via suppressing ACE/Ang-II/aldosterone pathway in rats', EKB Journal Management System, 38(1), pp. 75-89. doi: 10.21608/ejrsa.2025.387015.1186
Galal, S., Mansour, H., El Kiki, S. Bromelain diminishes renal consequences induced by gamma irradiation via suppressing ACE/Ang-II/aldosterone pathway in rats. EKB Journal Management System, 2025; 38(1): 75-89. doi: 10.21608/ejrsa.2025.387015.1186

Bromelain diminishes renal consequences induced by gamma irradiation via suppressing ACE/Ang-II/aldosterone pathway in rats

Egyptian Journal of Radiation Sciences and Applications
Volume 38, Issue 1, December 2025, Pages 75-89    PDF (1.81 M)
Document Type: Original Article
DOI: 10.21608/ejrsa.2025.387015.1186
Authors
Shereen Mohamed Galal* 1; Heba Hosney Mansour2; shereen mohamed El Kiki3
1Health Radiation Research Department, National Center for Radiation Research and Technology, Atomic energy authority
2Health Radiation Research Department, National Center for Radiation Research and Technology,
3health radiation research department, national center for radiation research and technology, atomic energy authority
Abstract
Radiation causes renal damage by enhancing the renin-angiotensin-aldosterone system's (RAAS) activation. This work aimed to evaluate the role of bromelain, an angiotensin-converting enzyme inhibitor (ACEI) in hindering the inflammatory and fibrotic impact of radiation via suppressing this pathway. Rats were subjected to a single dosage of 7.5 Gy then administered bromelain (30 mg/kg) orally for 14 days after one hour of irradiation. Gamma radiation caused a considerable increase in (RAAS) indices such as angiotensin II (AngII), aldosterone and angiotensin-converting enzyme (ACE) protein expression, in along with renal function: urea, creatinine and blood urea nitrogen with significant disturbance in oxidative stress markers: malondialdehyde (MDA), protein carbonyl (PCO), reduced glutathione (GSH), total thiol (tSH) and superoxide dismutase (SOD) in renal tissue homogenate. In addition, there was a notable increase in the renal inflammatory mediator's levels: tumor necrosis factor-α (TNF-α), nuclear factor kappa B (NF-κB) and interleukin-1β (IL-1β) alongside serum profibrotic markers: hyaluronic acid (HA), laminin (LN), type III procollagen (PCIII) and renal hydroxyproline (HYP) levels. Bromelain treatment dramatically improves the previously described parameters and modifies the radiation-induced renal histopathological damage in retaliation to the suppression of ACE, Ang II and aldosterone expressions.
Conclusions: Bromelain hinders radiation-induced inflammatory, fibrotic and oxidative stress response via remodelling the RAAS pathway in rats
Keywords
Bromelain; ACE; radiation; Angiotensin II; aldosterone
Statistics
Article View: 47
PDF Download: 39