Memory Changes in Patients with Major Depressive Disorder Treated with Electroconvulsive Therapy | ||
| Journal of Current Medical Research and Practice | ||
| Volume 10, Issue 4, October 2025, Pages 17-28 PDF (617.69 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jcmrp.2024.303183.1087 | ||
| Authors | ||
| Ayman N Abd Elhakeem* ; Alaa Eldin M Darweesh; Khaled A M Elbeh | ||
| Neurology Department, Faculty of Medicine, Assiut University, Assiut, Egypt. | ||
| Abstract | ||
| Introduction Depression is the most common mental health condition in the general population. Approximately 6-7% of full-time U.S. workers experienced major depression (MDD) within the past year. Electroconvulsive therapy is a first-line treatment for severely depressed patients; it may cause a temporary deficit in the cognitive processes of information encoding, consolidation, and retrieval. The present study aimed to: 1. Evaluate memory changes present in a sample of patients with major depressive disorder. 2. Differentiate the memory changes between unilateral electrode & bilateral electrode stimulation in patients with major depressive disorder. Patients and Methods The current study was an interventional study conducted at the Psychiatry Department, Asyut University Hospitals. From the 1st of October 2020, to the end of June 2021, the study included 40 patients aged 18-60 years old who presented with major depressive disorder according to DSM-5. Patients were assessed through (HAM-D), (MMSE), (MoCA)on admission, after treatment with ECT, and after 3-month follow-up. Result and Discussion It appears that there is no significant difference between unilateral & bilateral ECT stimulation in their efficacy of improving depression symptoms, and their effect in total cognitive function and memory affection as adverse events, however, the present study several parameters of ECT treatment and detailed study of cognitive functions are lacking, It is recommended to study a larger number of patients and details of cognitive functions have to be clarified in the future studies. | ||
| Keywords | ||
| ECT; Depression; Memory | ||
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