Evaluation of Renal Involvement in Inflammatory Bowel Disease | ||
| Journal of Current Medical Research and Practice | ||
| Volume 10, Issue 4, October 2025, Pages 29-36 PDF (466.24 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jcmrp.2025.305599.1094 | ||
| Authors | ||
| Hend Hamdy Tawfik* ; Enas Ahmed Reda Alkareemy; Nashwa Mostafa A.Azoz | ||
| Department of Internal Medicine, Assiut University Hospitals, Faculty of Medicine, Assiut University, Assiut, Egypt. | ||
| Abstract | ||
| Background and Aim: Inflammatory bowel disease (IBD) can develop various extra-intestinal manifestations. Renal manifestations develop in 4%-23% of patients with IBD. The study aimed to evaluate renal impairment in patients with IBD. Patients and Methods: The study enrolled a total of 60 patients with clinical, laboratory, radiological, and/or histopathological evidence of IBD (group A, included 30 patients with renal impairment (CKD group), and group B, included 30 patients with IBD with normal kidney function (Non-CKD group). All patients were subjected to thorough history taking and full clinical evaluation. In addition, reviewing their medical and endoscopic records to assess the severity of the disease. The following laboratory data were done; complete blood count, liver function tests, kidney function tests (blood urea, serum creatinine), urine analysis, 24-hours urinary proteins or urine ALB/Creat ratio, estimated glomerular filtration by Epi equation C3, C 4, ESR, CRP colonoscopy and ultrasound at the beginning of the study and 3rd and 6th month later as follow up. Results: Both groups (with/without CKD)had insignificant differences regarding baseline and follow-up after 3- and 6-month data, except for significantly impaired kidney function in the renal affection group. Also, patients with renal impairment had significantly longer duration of disease (4.70 ± 2.72 vs. 3.09 ± 1.98 (years). Predictors of renal impairment in patients with IBD were the age of the patients, longer duration of the disease, and amino salicylate therapy. Conclusion: patients with IBD are at higher risk for the development of renal affection. The predictors for renal enrolment are younger patients with longer duration of the disease and amino salicylates therapy in patients with inflammatory bowel disease. | ||
| Keywords | ||
| Renal affection; Inflammatory bowel disease; Amino salicylates | ||
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