Role of Intestinal Ultrasound in Monitoring the Response in Patients with Ulcerative Colitis under Biological Therapy | ||
| Journal of Current Medical Research and Practice | ||
| Volume 10, Issue 4, October 2025, Pages 37-50 PDF (691.33 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jcmrp.2025.356090.1203 | ||
| Authors | ||
| Zainab Gaber Mahran1; Abanoub Ayoub Melk* 1; Magda Sh.2; Hamdy Mohamed Ibrahim3; Mohamed Ahmed medhat2 | ||
| 1Department of Gastroenterology and Tropical Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt. | ||
| 2Department of Gastroenterology and Tropical Medicine, Faculty of Medicine, Assiut University. Assiut, Egypt. | ||
| 3Department Radiology, Faculty of Medicine, Assiut University. Assiut, Egypt. | ||
| Abstract | ||
| Background: Intestinal ultrasound (IUS) is a safe, fast, inexpensive method with high sensitivity and specificity, and is commonly used in many intestinal diseases, especially for diagnosing and monitoring inflammatory bowel diseases. IUS is now reported to be accurate for ulcerative colitis (UC). Aim: We aimed to evaluate the role of IUS in assessing the therapeutic response to biological therapy in patients with ulcerative colitis pre and post-treatment. Patients and Methods: Participants were diagnosed with UC. History and physical examination, labs, severity scores, colonoscopy, and intestinal ultrasound were done before and after induction doses of infliximab. Results: Fifty-two participants were initially evaluated. Among those patients, 6 underwent baseline investigations but were lost to follow-up. 63.5% males and 36.5% females. We found that IUS diagnosis of thickness of the Rectum at a threshold of mean thickness value of 4.8 mm was possible with sensitivity, specificity, and area under curve, PPV, NPV of 95%, 90%, 0.954, 94%, 78% respectively, while in sigmoid colon at mean thickness of 3.9 mm was 95%, 92%, and. 0.95, 93%, 82%, respectively. And in descending colon at a threshold of mean thickness value of 3.0 mm was 82%, 87%, 0.877, 91%, 75% respectively, and in transverse colon at thickness value of 3.1 mm was 84%, 82%, 0.69, 87%, 79% respectively, and in ascending colon at thickness value of 3.0 mm was 83%, 85%, and 0.685, 90%, 73% respectively. Conclusion: The accuracy of IUS in monitoring wall thickness in UC pre and post-biological therapy. Compared with other parts of the colon, high-performance characteristics were found in the Rectum. Trial registration: ClinicalTrials.gov ID: NCT05606939. | ||
| Keywords | ||
| Intestinal Ultrasound (IUS); Inflammatory Bowel Disease (IBD); Ulcerative Colitis (UC); Bowel Wall Thickness (BWT) | ||
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