Transcription Factor 7 Like 2 Gene Polymorphism in Diabetic Patients | ||
| Journal of Current Medical Research and Practice | ||
| Volume 10, Issue 4, October 2025, Pages 51-64 PDF (973.55 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jcmrp.2025.387479.1270 | ||
| Authors | ||
| Hala Saleh Abdalghafour* 1; Madeeha Younis Bakheet1; Ghadeer AbdelRazzak1; Ebtsam Farouk EL Karn1; Omnia Abd ElMoneim Mohamed1; Wlaa Anwar Khalifa2; Mohamed Zaharia Abu Rahma3; Dina A. Mohareb1 | ||
| 1Clinical Pathology Department, Faculty of Medicine, Assiut University Hospital, Assiut, Egypt. | ||
| 2Medicine Department, Assiut University Hospital, Assiut, Egypt. | ||
| 3Department of Tropical Medicine & Gastroenterology, Faculty of Medicine, Assiut University, Assiut, Egypt. | ||
| Abstract | ||
| Abstract: Introduction: Diabetes mellitus (DM) results from insulin resistance, inadequate secretion, and absolute insulin deficiency. DM is associated with macrovascular and microvascular complications. Microvascular complications like diabetic retinopathy, nephropathy, and peripheral neuropathy. The incidence and progression of DM may be influenced by genetic variation. Together with other genes, the transcription factor 7-like 2 (TCF7L2) gene may have had a role in the development of DM. TCF7L2 is an essential constituent of the Wnt signaling pathway and regulates beta cells' insulin release in the pancreas. Patients and Methods: Genotyping of single-nucleotide polymorphism (SNP) rs7903146 of the TCF7L2 gene (using PCR-RFLP) was studied on 54 diabetic patients, 18 prediabetic patients, and 18 apparently healthy individuals as a control group. Results: genotype distributions of TCF7L2 (rs7903146 C/T) SNP in the control group were (CC: 77.8% and CT: 22.2%), respectively, while in the prediabetic group, they were (CC: 55.6% and CT: 44.4%). In the diabetic group, the genotype frequencies were (CC: 27.8%; CT:57.4% and TT:14.8%) respectively. The result of allele distributions of the TCF7L2 (rs7903146 C/T) SNP in the control group was (C allele: 88.9% and T allele: 11.1%), respectively. The prediabetic group was (C allele: 77.8% and T allele: 22.2%) respectively. The diabetic group's frequencies were (C allele: 56.5% and T allele: 43.5%), respectively. The C allele of TCF7L2 (rs7903146 C/T) SNP was predominant in healthy controls. Conclusion: The T allele of TCF7L2 (rs7903146 C/T) SNP was associated with the susceptibility to the development of DM. | ||
| Keywords | ||
| Keywords: Single nucleotide; Genotype; Phenotype | ||
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