Efficiency of NiFe2O4 nanoparticles in treatment hospital effluent toxicity on liver, kidney, and testis of Wistar rats: CYP450 and FABP1 mechanisms | ||
| Egyptian Pharmaceutical Journal | ||
| Volume 24, Issue 4, October 2025, Pages 147-159 PDF (1.13 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/epj.2025.386193.1107 | ||
| Authors | ||
| Hend A Sabry* 1; Amr B Mostafa2; Elham HA Ali3; Amal A.E. Ibrahim4; Mai M Zahra5 | ||
| 1Zoology Department, Faculty of Science, Ain Shams University, Cairo, Egypt. | ||
| 2Zoology Department, Faculty of Science, Ain Shams University Cairo, Egypt. | ||
| 3Asma Fahmy St., PO Box 11586, Nasr City, Cairo, Egypt | ||
| 4Zoology Department, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo Egypt | ||
| 5Zoology Department, Faculty of Science, Ain Shams University Cairo, Egypt. | ||
| Abstract | ||
| Background Hospital effluents (HEs) include a wide variety of pathogens, because of technological and scientific developments. They pose a threat to society and the ecosystem. Objective The effects of nanotechnology on human health as it relates to HEs treatment were the primary spotlight of the current work. This study investigates the impact of recently emerging nanotechnology solutions for treating HEs on tissue damage. Material and methods Male experimental rats in 3 groups, 8 rats per each, were designed: Group “1” received tap water as a control, group “2” received HEs, and group “3” received nanocomposite hospital effluents (N-HEs) for 4 weeks, each group received an intragastric injection of each water type (2.5 ml/100 g body weight/six hours). At the end of the experiment, blood and tissues samples were collected, and some hematological, biochemical and histopathological assessments were measured. Results and conclusion The exposure to HEs treated with NiFe2O4 nanoparticles may reduce the dangers of HEs impairing tissue function. This improvement was shown by enhancing hematological parameters like erythrocyte, white blood cells, platelets count, hemoglobin content and the blood indices (MCV, mean corpuscular volume and MCH, mean corpuscular hemoglobin). Whereas an elevation of the level of cytochrome P450 (CYP450) and overall antioxidant activity, while decreasing contents of lipid peroxidation and fatty acid binding protein-1 (FABP1) in liver, kidney and testis tissues were noticed. Also, augmentation of the histopathology of the selected tissues was recorded. In summary, the magnetic NiFe2O4 nanoparticles are appropriate to remove 95% pharmaceutical residues from HEs entirely with low-cost-effectiveness, which in turn reflected on the reduction of toxicity in the liver, kidney and testis of the investigated rats. | ||
| Keywords | ||
| Hospital effluents; nanotechnology; FABP1; CYP450; toxicity; and total antioxidant activity | ||
|
Statistics Article View: 3 PDF Download: 6 |
||
