Whey supplementation alleviating brain damage of mother rats caused by a high fat diet | ||
| Mansoura Journal of Biology | ||
| Volume 50, Issue 1, March 2021, Pages 32-39 PDF (875.28 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjb.2021.460283 | ||
| Authors | ||
| Nariman Hanea Mohamed Nada* ; Heba Atef El-Ghaweet; Hassan IH El-Sayyad | ||
| Zoology Department, Faculty of Science, Mansoura University, Egypt | ||
| Abstract | ||
| The research work was done to observe the therapeutic potential of bovine whey supplementation in improving the brain damage of mother rats fed on a high fat diet. Twenty –four mother rats (Rattus norvegicus) (200-220 g b.wt) were used in this study. They were categorized into four groups; control, whey supplemented group (ad-libitum every other day), a high fat diet and high fat diet in combination with whey supplementation. Also, whey supplementation at doses of 2 cubic mL3 alone or in combination with a high fat diet every other day during the gestation and lactation period till 21 day-post-partum. Mother rats were sacrificed and their brain were dissected and subjected for biochemical investigations of DA,5-HT, TNF-α, Cas-3, TAC, SOD, MDA & GLUT-1. In brain of mother rats ingested a high fat diet, whey supplementation restored the decreased levels of SOD, TOC, DA, 5-HT and GLUT-1 and decreased the upregulation of MD, CAS-3 and TNF-α. These findings indicated that whey supplementation howed therapeutic potential against oxidative stress, inflammation and and apoptotic cell death as indicated by increased the level of caspase 3. The authors concluded that whey supplementation have therapeutic potential against maternal feeding on a high fat diet. They improve the brain from oxidative stress and inflammation while also increasing dopamine, serotonin and antioxidants levels which improve cognition | ||
| Keywords | ||
| Brain; high fat diet; whey; antioxidant; inflammation and neurotransmitters | ||
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