The Effect of Zn-Hydrazone Complex Against Solid Tumor In Mice | ||
| Mansoura Journal of Biology | ||
| Volume 50, Issue 1, March 2021, Pages 40-52 PDF (1.37 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjb.2021.460284 | ||
| Authors | ||
| Mariam Khater; Maher Amer Ali; Yasmina EL.tahrey; Sameh M. Shabana | ||
| Department of Zoology, Faculty of Science, Mansoura University, Mansoura, Egypt | ||
| Abstract | ||
| Chemotherapeutic treatment of cancer is commonly used even through it has detrimental side effects, specially the adverse effect on normal cells, therefore, The extension of the life span of tumor-bearing animals is a reliable criterion for judging the value of any novel anticancer drug. In the current study the effect of Zn-hydrazone complex (ZHC) against experimentally induced solid tumor was investigated. The solid tumor was induced by injecting sc.injection of EAC cells into each experimental animal's right hind limb. After 24hrs of the tumor cell inoculation, mice were treated at a dose 160 mg/kg (i.p) Once daily for month , according to their respective groups. Results showed significant increase in survival rate and a significant decrease in tumor volume after treatment. In addition, ZHC induced cell cycle arrest in G0/G1 and apoptosis. These effects were supported by inhibition of Ki-67 and PCNA, activation of P53 and Bax and down regulation in Bcl-2 levels in solid tumor cells. SOD, Gpx, GSH, and TAC levels increased significantly, while MDA levels decreased significantly | ||
| Keywords | ||
| Ehrlich ascites carcinoma; Zn-hydrazone complex; Apoptosis; Antioxidants; Cell cycle; Chemoprevention | ||
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