A RETROSPECTIVE STUDY FOR THE USE OF TISSUE ENGINEERING IN ORAL & MAXILLOFACIAL SURGERY (A SYSTEMATIC REVIEW) | ||
| PUA Dental Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 20 October 2025 | ||
| Document Type: Review | ||
| DOI: 10.21608/puadent.2025.427287.1010 | ||
| Authors | ||
| Aliaa Ahmed Habib* 1; Mahitab Mahmoud Soliman2 | ||
| 1Lecturer in Oral Surgery Department, Pharos University, Alexandria, Egypt | ||
| 2Oral Surgery, Pharos University , Alexandria | ||
| Abstract | ||
| Background: The present study is a systematic review concerned with the utilization of tissue engineering in alveolar bone defect healing in vivo using Dental pulp stem cells (DPSCs), Mesenchymal stem cells (MSCs), or "Adipose-derived stem cells (ADSCs). Methods: Gathering databases including PubMed, Medline, and Science Direct. A systematic review of the literature spanning 2018 to 2025 was conducted. The primary criteria for including in vivo studies were those that presented quantitative data on new bone volume and area. The quality of these studies was evaluated using Cochrane’s checklist. The procedure for selecting articles to be searched was illustrated using a PRISMA flowchart. Results: This study review encompassed a total of 72 investigations, of which 10 studies met the inclusion criteria and demonstrated that the use of tissue engineering with DPSCs, MSCs, or ADSCs yields results noticeably superior to those of conventional grafting techniques (control group). Conclusion: This systematic review demonstrated that DPSCs, MSCs, and ADSCs play a significant role in the regeneration of bone tissue complexes in tissue regeneration therapy. Nonetheless, conducting a wider range of pre-clinical studies would be beneficial for facilitating more robust meta-analyses in the future. | ||
| Keywords | ||
| Tissue Engineering; Dental Pulp Stem Cells; Mesenchymal Stem Cells; Adipose-Derived Stem Cells; Tissue Regeneration | ||
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