Piperonyl butoxide induced reproductive toxicity in male mice | ||
| Journal of Pest Control and Environmental Sciences | ||
| Volume 8, Issue 1, April 2000, Pages 107-123 PDF (355.21 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jpces.2000.460493 | ||
| Authors | ||
| Amina T. Farag* 1; Anisa E. Melies2 | ||
| 1Department or Pesticide Chemistry, Faculty of Agriculture, Alexandria University, Egypt. | ||
| 2Department of histology, Faculty of Medicine, Alexandria University, Egypt. | ||
| Abstract | ||
| The effect of piperonyl butoxide (PBO) on reproductive performance of male mice was investigated Male CD-I mice (20 mice/group) were administered piperonyl butoxide in the diet at levels of O (control), 0. l, 0.3, and 0.6% for 4 weeks (20 days) Reduction of sperm measurements was induced in all the treated groups in a dose-dependent manner. PBO caused obvious adverse effects in pregnancy outcomes including decreased the number of implantations and live fetuses, increased number of early resorptions and dead fetuses in all the treated groups. The testicular toxicity was observed in all the treated groups. Testes and epididymis weights were reduced and severe histological changes in testes appeared in all the treated groups, especially at the higher dose level group (0.6%). On the basis of the present results and under the condition of this investigation and at the tested levels, PBO showed potential reproductive toxicity. | ||
| Keywords | ||
| Piperonyl butoxide; reproductive toxicity; male mice | ||
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