Serum interleukin-17 expression in postmenopausal women and its relation to osteoporosis and risk of fractures | ||
| Journal of the Arab Society for Medical Research | ||
| Volume 20, Issue 1, January 2025, Pages 61-67 PDF (390.07 K) | ||
| DOI: 10.4103/jasmr.jasmr_34_24 | ||
| Abstract | ||
| Background/Aim Osteoporosis is a musculoskeletal disorder that is characterized by low bone mineral density (BMD) as well as an elevated risk of fractures. We aim to investigate the expression of interleukin-17 (IL-17) in postmenopausal women and to assess its relation to BMD and fracture risk. Patients and methods A case-control study included sixty postmenopausal female Patients were gathered from the Outpatient Clinic of the Rheumatology, Rehabilitation and Physical Medicine Department, Faculty of Medicine, Menoufia University, Egypt. All participants were divided into two groups; patients group, which enrolled 30 Postmenopausal females diagnosed as having osteoporosis, and control group, which included 30 Postmenopausal females without osteoporosis. All participants were exposed to clinical, anthropometric, and radiological examinations, as well as assessments of serum levels of total and ionized calcium by the colorimetric methods, 25 hydroxy vitamin D, parathyroid hormone, Estradiol level (E2) by chemiluminescent immunoassay, in addition to the serum level of IL-17 using ELISA technique. Results The present study exhibited significant increase (P<0.05) in IL-17 level and significant decrease (P<0.05) in estradiol level in patients group compared with controls. Moreover, significant differences were found in fracture risk assessment instrument tool analysis for the 10 year probability of major osteoporotic fractures (P>0.05) and hip fracture (P>0.05). Osteoporotic group demonstrated higher mean probabilities for both types of fractures compared with normal group. IL17 level exhibited negative correlations with DEXA score and serum estrogen level but exhibited positive correlation with fracture risk assessment instrument tool. Conclusion This study demonstrated a comprehensive evidence for the complex interactions among IL-17, BMD, and fracture risk in postmenopausal women. The elevated IL-17 levels in osteoporotic women and their correlation with fracture risk probabilities suggest a potential role for this cytokine in osteoporosis pathogenesis and risk assessment. | ||
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