Biosynthesis and Biomedical Applications of Selenium Nanoparticles Synthesized by Actinomycetes: A Review | ||
| International Journal of Theoretical and Applied Research | ||
| Articles in Press, Accepted Manuscript, Available Online from 20 October 2025 PDF (769.58 K) | ||
| Document Type: Review articles | ||
| DOI: 10.21608/ijtar.2025.409216.1137 | ||
| Authors | ||
| marwa elshazly mohmmed* 1; Rawhia abdelmonem arafaa2; Inas Mohammed Abou El-Enain3; mohammed hosney Mourad4; Ahmed Shalbi Hamed5 | ||
| 1Department of Microbiology/Chemistry Faculty of Science, Al-Azhar University Cairo, Egypt | ||
| 2Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Girl’s branch, Cairo, Egypt | ||
| 3Botany and Microbiology department, Faculty of science, Al-Azhar University girls branch, Cairo, Egypt | ||
| 4The Regional Center for Mycology and Biotechnology, Al-Azhar University, Nasr City, Cairo, Egypt | ||
| 5Microbiology and Chemistry Department, National Research Center, Al-Dokki, Cairo, Egypt | ||
| Abstract | ||
| Selenium nanoparticles (SeNPs) have emerged as potential nanomaterials due to their biocompatibility, bioavailability, and low toxicity, making them ideal for a wide range of biomedical applications. Although SeNPs may be manufactured via physical, chemical, and biological processes, biological approaches are gaining popularity because to their environmental friendliness and improved bioactivity. Actinomycetes, as microbial systems, constitute a novel and underexplored platform for SeNP biosynthesis due to their unique metabolic capability, generation of bioactive metabolite, and ability to create nanoparticles of regulated size and stability. These nanoparticles are confirmed and characterized using advanced analytical methods such as UV-Vis spectroscopy, FTIR, XRD, SEM, EDX, and DLS. This study emphasizes the unique function of actinomycetes in sustained SeNP synthesis and critically examines their medicinal uses, which range from antibacterial and antifungal activities to antioxidant, anticancer, and antidiabetic therapy. By stressing the benefits of actinomycete-mediated synthesis over traditional approaches, this work highlights actinomycetes' originality and future promise as efficient bio factories for SeNPs in biomedical research. | ||
| Keywords | ||
| Biocompatibility; Cytotoxicity; Antimicrobial | ||
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