Role of radish root extract in modulating doxorubicin- induced cardiotoxicity in male rats | ||
Mansoura Journal of Biology | ||
Volume 48, Issue 3, September 2020, Pages 1-12 PDF (1.14 M) | ||
Document Type: Research Article | ||
DOI: 10.21608/mjb.2020.460683 | ||
Authors | ||
Shaimaa Abdel-Shafy* ; Azza M. El-Wakf; El-Sayed M. El-Habibi | ||
Zoology Department, Faculty of Science, Mansoura University, Egypt | ||
Abstract | ||
This study aimed to evaluate the role of radish root extract (RRE) in modulating doxorubicin (DOX)- induced cardiotoxicity in male rats. DOX was injected intraperitoneally in 8 equal doses (each containing 2.5mg/kg BW) twice weekly for 4 weeks, whereas RRE (30mg/kg BW) was given orally, 6 days/week for the same duration. DOX-treated rats elicited marked increase in serum levels of cardiac troponin-I and enzymes; creatine kinase-MB, lactate dehydrogenase and aspartate aminotransferase, with significant decrease in the body weight (BW), heart weight (HW) and heart /body weight ratio. Results also showed increased cardiac xanthine oxidase , malondialdehyde, protein carbonyl and nitric oxide , with decreased antioxidants; reduced glutathione , superoxide dismutase and catalase, as well as total antioxidant capacity. Increased serum inflammatory markers (tumor necrosis factor α and C-reactive protein), and adhesion molecules (intercellular adhesion molecule-1 and vascular cell adhesion molecule-1) were also recorded. Besides, a decrease in RBCs count, Hb content, Ht%, MCV, MCH and platelets count with increased leucocytes count were observed. Supplementation of RRE tended to protect against DOX-induced cardiotoxicity, as evidenced via normalizing heart weight, cardiac biomarkers, oxidative stress and inflammatory response. Thus, recommendation for regarding consumption of RRE during DOX treatment should be made. | ||
Keywords | ||
Radish root extract; doxorubicin; oxidative stress; inflammation; heart weight; cardiac biomarkers | ||
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