The protective effect of ascorbic acid and β-carotene against toxicity induced by malathion in male albino rats | ||
| Journal of Pest Control and Environmental Sciences | ||
| Volume 14, Issue 2, December 2006, Pages 191-206 PDF (196.68 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jpces.2006.460745 | ||
| Author | ||
| Kadry Weshahy* | ||
| Department of Plant Protection, Faculty of Agriculture, Ain Shams University, Shobra El–Kheima, Cairo | ||
| Abstract | ||
| The objectives of the present study were to evaluate the possible protective effects of ascorbic acid (vitamin C) and β–carotene as antioxidants against the toxicity induced by malathion on male albino rats. Sixty of adult male albino rats were randomly assigned to six equal groups including control group. Animals were orally treated with either ascorbic acid (10 mg / kg b.w), β– carotene (10 m / kg b.w), acute dose of malathion (470 mg / kg b.w which equivalent ½ LD50), ascorbic acid plus malathion or β–carotene plus malathion. Ingestion of acute dose of malathion caused a significant increase in levels of MDA (malondialdhyde) in liver and kidney of male rats, SOD (superoxide dismutase) in erythrocytes and CAT (catalase) in liver of male rats. It significantly decreased GSH (reduced glutathione) activity in liver and kidney of male rats after 4, 8, 16, 32 and 64 hours of treatments. The treatments with ascorbic acid and β–carotene plus malathion have not cause any significant change in all parameters in treated male rats, compare with untreated group. The treatment with ascorbic acid plus malathion resulted pronounced fall in that values of MDA, SOD and CAT activities in treated male rats as compared to those malathion treatment. On the other hand, an elevation in GSH had been recognized over these of malathion administered male rats. Also, the male rats that treated with β–carotene showed a significant improvement in the level and activities of all parameters compared with male rats which treated with malathion. | ||
| Keywords | ||
| Malathion; toxicity; MDA; CAT; SOD; GSH; ascorbic acid; β-carotene | ||
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