Pharmacokinetics and excretion of ametryn in rat following a single oral administration | ||
Journal of Pest Control and Environmental Sciences | ||
Volume 5, Issue 1, June 1993, Pages 61-76 PDF (776.82 K) | ||
Document Type: Original Article | ||
DOI: 10.21608/jpces.1993.460811 | ||
Authors | ||
Ahmed K. Salama* ; Mohamed A. Radwan; Nabila M. Bakry | ||
Plant Protection Dept., Pesticide Chemistry Div., Faculty of Agriculture, University of Alexandria, Alexandria, Egypt | ||
Abstract | ||
Pharmacokinetics and excretion of ametryn (2-ethy1amino-4-isopropyl amino-6-methylthio-s-triazine) following a single oral dose of 10 mg/kg were investigated in female rats. Animals were killed at time intervals of 15min 1, 6, 12, 24, 48, 72, 96 hr, and 7 days. On the basis of gran tissue, brain concentration of ametryn was higher than in plasma at the first time intervals. The values were 0.40 and 0.07 ug/g (mL) which accounted for .07 and .01* of the applied dose, respectively. The daily rate of elimination in the excrements was found to increase slowly with time until two days after dosing. Following this, there was a slower rate of excretion of the herbicide. Approximately 4.2% of the dose was eliminated in the excreta throughout the seven days experiment. The concentrations of residual ametryn in both brain and plasma tissues declined exponentially by time. The half-life values of the elimination of ametryn from brain and plasma were 3.58 and 4.0 days corresponding to the rate constant values of 0.19 and 0.17 day-1, respectively. Brain AUC (area under the curve) va1ue was 1680 mg.hr/kg, indicating that there was no tendency for the compound to be retained in the plasma compared with the brain. | ||
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