Genotoxicity of systemic pesticide confidor in male albino mice a- blood serum enzymes as an index
El-Sheikh, A., Ammar, I., Eissa, R. (1993). Genotoxicity of systemic pesticide confidor in male albino mice a- blood serum enzymes as an index. EKB Journal Management System, 5(2), 75-89. doi: 10.21608/jpces.1993.460817
A. E. A. El-Sheikh; I. M. A. Ammar; Ragaa A. Eissa. "Genotoxicity of systemic pesticide confidor in male albino mice a- blood serum enzymes as an index". EKB Journal Management System, 5, 2, 1993, 75-89. doi: 10.21608/jpces.1993.460817
El-Sheikh, A., Ammar, I., Eissa, R. (1993). 'Genotoxicity of systemic pesticide confidor in male albino mice a- blood serum enzymes as an index', EKB Journal Management System, 5(2), pp. 75-89. doi: 10.21608/jpces.1993.460817
El-Sheikh, A., Ammar, I., Eissa, R. Genotoxicity of systemic pesticide confidor in male albino mice a- blood serum enzymes as an index. EKB Journal Management System, 1993; 5(2): 75-89. doi: 10.21608/jpces.1993.460817

Genotoxicity of systemic pesticide confidor in male albino mice a- blood serum enzymes as an index

Journal of Pest Control and Environmental Sciences
Volume 5, Issue 2, December 1993, Pages 75-89    PDF (754.17 K)
Document Type: Original Article
DOI: 10.21608/jpces.1993.460817
Authors
A. E. A. El-Sheikh* 1; I. M. A. Ammar1; Ragaa A. Eissa2
1Pesticide Dept., Fac. of Agric., Menofiya Univ., Egypt.
2Genetics Dept., Fac. of Agric., Menofiya Univ., Egypt.
Abstract
The genotoxic effect of systemic pesticide confidor was studied in male albino mice on gene expression (as key enzymes) such as alkaline phosphatase acetyl, cholinesterase, glutamic pyruvic transaminase (GPT), glutamic-oxaloacetic transaminase (GOT) and total protein in blood serum. Confidor was given orally either as a single dose (1/4 LD50), sacrificing the animals 24, 48, and 69 hours post treatment, or as repeated dose using either 1/4 LD50 dose for four consecutive days or 1/10 LD50 for ten days. The calculated LD50 was 210 body weight. Serum albumin showed a gradual significant increase in quantity over 96 hr being higher in single dose treatment. Whereas globulin showed the opposite response. Confidor imposes a significant inhibitory effect on total protein biosynthesis, showing sever action at repeated doses as the time passed on. Aminotransferases enzymes (GPT and GOT) experienced biosynthesis inhibition under both scheme of treatment.  Though there was a leveling up in GPT synthesis under repeated doses at 48 hr post treatment. In general cholinesterase and alkaline phosphatases.
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