Serum levels of monocyte chemoattractant protein-1, interlukin-6, and paraoxonase-1 in childhood obesity
Abd El Hamid, E., Abdel-Shaheed, A., Sabry, R., Youness, E., Abu Shady, M., Megawer, A., Mohamed, N. (2015). Serum levels of monocyte chemoattractant protein-1, interlukin-6, and paraoxonase-1 in childhood obesity. EKB Journal Management System, 10(1), 27-31. doi: 10.4103/1687-4293.159371
Enas R. Abd El Hamid; Azza A. Abdel-Shaheed; Rania N. Sabry; Eman R. Youness; Mones M. Abu Shady; Amr Said Megawer; Nadia A. Mohamed. "Serum levels of monocyte chemoattractant protein-1, interlukin-6, and paraoxonase-1 in childhood obesity". EKB Journal Management System, 10, 1, 2015, 27-31. doi: 10.4103/1687-4293.159371
Abd El Hamid, E., Abdel-Shaheed, A., Sabry, R., Youness, E., Abu Shady, M., Megawer, A., Mohamed, N. (2015). 'Serum levels of monocyte chemoattractant protein-1, interlukin-6, and paraoxonase-1 in childhood obesity', EKB Journal Management System, 10(1), pp. 27-31. doi: 10.4103/1687-4293.159371
Abd El Hamid, E., Abdel-Shaheed, A., Sabry, R., Youness, E., Abu Shady, M., Megawer, A., Mohamed, N. Serum levels of monocyte chemoattractant protein-1, interlukin-6, and paraoxonase-1 in childhood obesity. EKB Journal Management System, 2015; 10(1): 27-31. doi: 10.4103/1687-4293.159371

Serum levels of monocyte chemoattractant protein-1, interlukin-6, and paraoxonase-1 in childhood obesity

Journal of the Arab Society for Medical Research
Volume 10, Issue 1, January 2015, Pages 27-31    PDF (134.53 K)
DOI: 10.4103/1687-4293.159371
Authors
Enas R. Abd El Hamid; Azza A. Abdel-Shaheed; Rania N. Sabry; Eman R. Youness; Mones M. Abu Shady; Amr Said Megawer; Nadia A. Mohamed
Abstract
Background/aim
Obesity is becoming an epidemic health problem. Elevated cytokines and chemokines are prominent features in obesity, which play a main role in the development of other chronic diseases. The aim of this study was to determine the serum levels of monocyte chemoattractant protein-1 (MCP-1), interlukin-6 (IL-6), and serum paraoxonase-1 (PON1) in childhood obesity.
Materials and methods
The present study included 40 obese school-aged children (5–15 years) and 40 healthy children as controls. The patients were presented to the outpatient clinic in National Institute of Nutrition. MCP-1, IL-6, PON1, total cholesterol, and triglycerides were measured in all participants.
Results
The mean serum levels of MCP-1, IL-6, and total cholesterol were significantly higher in obese participants than in controls ( < 0.0001), whereas the PON1 was significantly lower in obese participants than in controls ( < 0.0001). MCP-1, IL-6, and serum cholesterol levels showed significant positive correlation with BMI ( < 0.05), whereas PON1 showed a significant negative correlation with BMI ( < 0.05). Multiple regression analysis showed a strong association between PON1 activity and BMI ( < 0.0001).
Conclusion
Childhood obesity is associated with increased serum MCP-1 and IL-6 and decreased PON1 and hypercholesterolemia suggesting an increase in adulthood disease risk. Measuring serum MCP-1, IL-6, PON1 activity in obese children may be a good predictor for future chronic disease development and complications.
Keywords
Interleukin-6; Monocyte Chemoattractant Protein-1; Obesity; Paraoxonase-1
Statistics
Article View: 2
PDF Download: 1