Cardioprotective effects of vitamin B complex and Ethinyl Estradiol in ovariectomized rats | ||
| Journal of the Arab Society for Medical Research | ||
| Volume 12, Issue 2, July 2017, Pages 39-45 PDF (123.6 K) | ||
| DOI: 10.4103/jasmr.jasmr_6_17 | ||
| Authors | ||
| Bassant M.M. Ibrahim; Hanan F. Al-Saeed; Aziza B. Shalby | ||
| Abstract | ||
| Background/aim Reduction of female sex hormones is associated with health disorders including cardiovascular diseases such as hypertension. Supplementation with vitamin B complex can lower the incidence of these disorders. The present study aimed to study the potential cardioprotective effects of vitamin B complex and ethinyl estradiol (EE) when administered alone or in combination to hormonal-deprived ovariectomized (OVX) rats. Materials and methods Fifty female Wister rats were classified into five equal groups: the first group included normal rats, the second group was OVX (positive control), and the third to fifth groups were OVX rats that were treated by EE (0.03 mg/kg), vitamin B complex (9.036 mg/kg), and a combination of both treatments, respectively. Treatment continued for eight successive weeks. Blood pressure (BP), cystathionine γ-lyase (CSE), reduced glutathione (R-GSH), superoxide dismutase (SOD), catalase (CAT), and interleukin-β6 (IL-β6) were measured. Results The OVX rats showed a significant increase in BP, reduction in CSE, R-GSH, SOD, and CAT, and increase in IL-β6 levels, whereas the treated OVX rats showed a significant decrease in BP, increase in CSE, R-GSH, SOD, and CAT, and reduction in IL-β6 levels. Conclusion Vitamin B complex and EE exert cardioprotective effects in OVX rats. | ||
| Keywords | ||
| blood pressure; cystathionine γ-lyase; Ethinyl Estradiol; Ovariectomy; Oxidative Stress; Vitamin B | ||
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