Clinical efficacy of nicotine replacement therapy in the treatment of minor recurrent aphthous stomatitis | ||
| Journal of the Arab Society for Medical Research | ||
| Volume 13, Issue 2, July 2018, Pages 106-112 PDF (367.91 K) | ||
| DOI: 10.4103/jasmr.jasmr_26_18 | ||
| Authors | ||
| Mai Zakaria; Aliaa El-Meshad | ||
| Abstract | ||
| Background/aim Recurrent aphthous stomatitis (RAS) is a common and widely recognized disease involving the oral mucous membrane. Nicotine replacement therapy (NRT) is a dose-dependent safe method for encountering useful effects of nicotine. This study aimed to evaluate the clinical efficacy of NRT in the treatment of minor RAS. Materials and methods A total of 50 patients from Oral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, with active minor RAS lasting for less than 48 h were randomly allocated into two groups (25 each): placebo and nicotine groups. They were treated with placebo and 2-mg nicotine chewing gum, correspondingly, twice daily for 2 weeks. All participants were assessed for pain, erythema, and ulcer size sores at 4 and 6 days from baseline. Frequency of recurrence was evaluated at 1-month, 2-month, and 3-month intervals. Results Regarding pain and erythema scores, the nicotine group showed lower mean with significant difference after 6 days in comparison with the placebo group. A lower mean of ulcer size was recorded in the nicotine group, with a significant difference after 4 and 6 days. A lower mean of recurrence score was recorded in nicotine group, with nonsignificant difference compared with the placebo group. Conclusion Low-dosage NRT in the form of chewing gum may be considered as an innovative and safe alternate treatment modality for minor RAS. | ||
| Keywords | ||
| chewing gum; erythema; Nicotine; Pain; Recurrence; Recurrent aphthous stomatitis | ||
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