Role of follicular fluid leptin hormone in women with polycystic ovarian syndrome in assisted reproductive technology | ||
| Journal of the Arab Society for Medical Research | ||
| Volume 16, Issue 1, January 2021, Pages 75-83 PDF (108.26 K) | ||
| DOI: 10.4103/jasmr.jasmr_8_21 | ||
| Abstract | ||
| Background/aim Granulosa cells have the capacity for producing and storing leptin, proposing that this hormone is locally involved in regulating follicular growth. The aim of this work was to evaluate the levels of follicular fluid (FF) leptin hormone and its correlation with pregnancy outcome in polycystic ovarian syndrome (PCOS) cases undergoing intracytoplasmic sperm injection cycles using both long gonadotrophin-producing hormone (GnRH) agonist and fixed GnRH antagonist protocols. Patients and methods This was a randomized controlled trial that included 100 patients with PCOS from the reproductive unit of Alexandria University Hospitals, Egypt, who were randomly allocated in two groups (50 patients ech): group 1 included patients with PCOS undergoing long GnRH agonist protocol, and group 2 included patients with PCOS undergoing fixed GnRH antagonist protocol. Anthropometric measurements were done, in addition to assays of FF leptin, serum Anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), luteinizing hormone, estradiol, and progesterone levels, assessed by enzyme-linked immunosorbent assay techniques. Results FF leptin had a highly significant increase in nonpregnant patients when compared with pregnant patients in both groups. In addition, there were significant increases in BMI and weight, whereas insingnificant difference regarding height between nonagonist and antagonist groups. Conclusion Leptin can negatively influence in-vitro fertilizations outcomes via weakening several stages of endometrial and ovarian physiology. The exact function of leptin in the poorer outcomes commonly found in obese cases throughout controlled ovarian stimulation needs to be explained, and there is a need to assess the correlation between free bioactive leptin and in-vitro fertilizations cycle parameters. | ||
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