Characterization and ameliorative effects of hydroethanolic extract against diethylnitrosamine-induced hepato-renal damage and malfunction | ||
| Journal of the Arab Society for Medical Research | ||
| Volume 18, Issue 2, July 2023, Pages 149-160 PDF (2.34 M) | ||
| DOI: 10.4103/jasmr.jasmr_7_23 | ||
| Abstract | ||
| Background/aim genus has broad applications in folk medicine. ( exhibited several pharmacological benefits, including hypotensive, anti-inflammatory, analgesic, antifungal, antibacterial, phytotoxic, hepatoprotective and renoprotective effects. The principal objective unveils the preventive effects of against hepato-renal damage and malfunction induced by diethylnitrosamine (DEN). Materials and methods Forty rats were included in the present study divided into 4 groups, group 1, animals were given saline solution every day for 14 weeks. Group 2, animals were injected double times per week by intraperitoneal route with DEN at 150 mg/kg body weight for 2 weeks. Animals in group 3 were injected with DEN like in group 2 and subjected orally to hydroethanolic extract (500 mg/kg body weight) daily for 14 weeks. Animals in group 4 received the same dose of the hydroethanolic extract of for a similar period. Results DEN has injurious effects, associated with elevated liver enzyme activities (AST, ALT and ALP), urea and creatinine in serum. Also, lipid peroxidation and nitric oxide were elevated markedly. DEN lowered the hepatic and renal activities of endogenous antioxidants (CAT and SOD), reduced glutathione (GSH) level. Conversely, treatment with restored liver function biomarker activities, urea and creatinine levels as well as mitigated the oxidative damage induced by DEN. reflecting its ameliorative potential which diminished obviously the DEN-induced elevated hepato-renal levels of IL-1β and TNF-α (immuno- inflammatory indicators), also down regulated Bcl-2, NF-κB, and Nrf-2 (inflammatory mediators). Conclusion These findings proved that might protect and ameliorate DEN-induced hepato-renal damage through activation of antioxidant and anti-inflammatory systems. | ||
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