Second Trimester Serum Calprotectin in Prediction of Early Onset Preeclampsia | ||
| Evidence Based Women's Health Journal | ||
| Volume 15, Issue 15, January 2025, Pages 1-7 PDF (383.56 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ebwhj.2025.405165.1487 | ||
| Authors | ||
| Wael Samir Elgazayerli* 1; Samir Elsaid2 | ||
| 1Obstetrics and gynaecology Alexandria University | ||
| 2Department of obstetrics and gynaecology Alexandria university | ||
| Abstract | ||
| Objectives: To evaluate the association of serum calprotectin in early second trimester between 14th to 16th weeks and development of early onset preeclampsia <34wks. Study design: This prospective observational study was conducted on 60 pregnant females at gestational age 14th to 16th weeks attending obstetrics clinic of ELShatby University Hospital, after approval of the local ethical committee and having informed written consent for every female included in the study. Results: A total of 60 pregnant women participated in the study after applying inclusion and exclusion criteria. The overall incidence of preeclampsia in the study was 10%, while the incidence of Gestational hypertension was 15%. As regard serum calprotectin , there was no statistically significant difference between preeclamptic and non preeclamptic groups (p= 0.962). Conclusion: The low levels of serum Calprotectin in the current study is most probably due to proteolysis either in vivo due to the uncontrolled MPO derived oxidative stress or pre-analysis, during sample handling and storage. Calprotectin proteolysis in the current work stands as a limitation in the use of CLP as a predictor of preeclampsia | ||
| Keywords | ||
| Elshatby University Hospital; preeclampsia; serum calprotectin | ||
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