Expression Levels of EIF4EBP1 in Colorectal Cancer: PBMCs versus Tissues | ||
| Egyptian Journal of Medical Microbiology | ||
| Articles in Press, Accepted Manuscript, Available Online from 23 October 2025 | ||
| Document Type: New and original researches in the field of Microbiology. | ||
| DOI: 10.21608/ejmm.2025.430697.1916 | ||
| Authors | ||
| Esraa H. Mohamed1; Mohamed A. Elfeky1; Salwa M. Seifeldein1; Mohamed A.S. Mahmoud2; Aliaa M. Ghandour* 1 | ||
| 1Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Egypt | ||
| 2Department of Surgical Oncology, South Egypt Cancer Institute, Assiut University, Egypt | ||
| Abstract | ||
| Background: The autophagy is a physiological mechanism by which the cells break down and rapidly rebuild the cell components. The autophagy is crucial for the onset, the progression, the management, and the prognosis of colorectal cancer (CRC). Objectives: This study aimed to evaluate the diagnostic and the prognostic roles of the autophagy-related gene (ARG) eukaryotic translation factor 4E binding protein 1 (EIF4EBP1) in the CRC patients. Methodology: This study included 30 CRC patients and 30 healthy controls. The gene expression of EIF4EBP1 in the peripheral blood mononuclear cells (PBMCs) and the tissue using the real-time PCR (RT-PCR) was done. Results and Conclusion: The PBMCs and tissue expression levels of EIF4EBP1 were upregulated in the CRC cases with higher tissue expression than that of PBMCs. Receiver Operating Characteristic Curve (ROC) analysis showed the ability of EIF4EBP1 tissue and PBMCs expression levels to diagnose CRC and differentiate between grade II and III CRC. | ||
| Keywords | ||
| Autophagy; EIF4EBP1; CRC | ||
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