NEUROTOXICITY EFFECTS OF ACETAMIPRID ON NEUROBEHAVIORAL, SPATIAL LEARNING AND MEMORY INADULT MICE | ||
| Assiut Veterinary Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 23 October 2025 PDF (432.46 K) | ||
| Document Type: Review article | ||
| DOI: 10.21608/avmj.2025.366352.1616 | ||
| Authors | ||
| SINAN MOHAMMED SHERIF; MUNA HAZIM AL-ZUBAIDY* | ||
| Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, Iraq. | ||
| Abstract | ||
| One of the most efficient neonicotinoid pesticides in the world for protecting crops and controlling flea infestations in livestock and pets is acetamiprid. There is unclear information on neurobehavioral and toxicity at low doses. The current study analyzed the potential neurotoxicity and neurobehavioral (spatial learning and memory) of acute acetamiprid oral administration in adult mice. The acute oral LD50 by up and down technique and recording the acute toxicity signs of acetamiprid as a formulation and assessing the effects of low doses of acetamiprid on the open-field, head pocking, negative geotaxis, maze T, and hanging tests. The oral LD50 dose of acetamiprid was 129.5 mg/kg. The mice treated with toxic percentages (25, 50, 75, and 100) % of LD50 suffered from dyspnea, lethargy, lacrimation, pawing, convulsion, hypothermia, gasping, and death. Acetamiprid decreased the overall locomotor activity of the mice in the open-field arena, as manifested by a significant decrease in line crossing, number of rearing compared to control values. The result of the Maze T test indicated that acetamiprid-treated groups at a dose (12.59 mg/kg) had a lower percentage alternation, compared to the control group. Oral administration of acetamiprid at a dose of 12.59 mg/kg led to a significant decrease in the time required for the mice to remain attached to the wire, compared to the control group. The data suggests acute exposure to acetamiprid affects memory and spatial learning in the T Maze, and open–field and causes muscle weakness in the Hanging test. Therefore, people who are exposed to acetamiprid on a regular basis, such as those who work in agriculture or in factories that manufacture pesticides, may be at neurotoxic risk of acetamiprid. | ||
| Keywords | ||
| Acetamiprid; Spatial learning; Memory; mice | ||
|
Statistics Article View: 2 PDF Download: 1 |
||
