An Overview of Neonatal Seizures in the Neonatal Intensive Care Unit of Assiut University Children's Hospital: A Cross-sectional Study | ||
| Journal of Current Medical Research and Practice | ||
| Volume 10, Issue 4, October 2025, Pages 111-122 PDF (575.47 K) | ||
| Document Type: Original Article | ||
| Authors | ||
| Ahmed Mohamed Salama* ; Emad El-Deen Mahmoud Hammad; Safwat Mohammed Abdel-Aziz | ||
| Pediatrics Department, Faculty of Medicine, Assiut University, Assiut, Egypt. | ||
| Abstract | ||
| Seizures are critical indicators of neurological dysfunction in newborns. They are characterized by a temporary manifestation of signs and/or symptoms resulting from abnormally excessive or synchronous neuronal activity in the brain. Seizures in neonates can be categorized into several types: clinical-only seizures, electro-clinical seizures, electrographic-only seizures, epilepsy, and status epilepticus..[1] Patients and Methods This hospital-based cross-sectional study was conducted in the Neonatal Intensive Care Unit of Assiut University Children's Hospital from July 2022 to March 2023, lasting about 9 months without interruptions. Results and Conclusion The findings of this study contribute significantly to the understanding of neonatal seizures. The study demonstrates that 19.5% of neonates experienced clinical seizures, primarily subtle in nature, alongside the identification of hypoxic ischemic encephalopathy as the predominant etiological factor. The study's EEG evaluations revealed various patterns, including burst-suppression and generalized discharge among the participant neonates showing convulsive phenomena. Importantly, there is a statistically significant difference in the maturity and birth weight of convulsing versus non-convulsing neonates, in contrast to the lack of significant differences regarding mean gestational age, sex, and mode of delivery, which points to specific risk factors associated with neonatal seizures. These results underline the necessity for thorough and multi-dimensional assessments in diagnosing and managing neonatal seizures, providing valuable insights for clinical practices and future research. | ||
| Keywords | ||
| Neonatal seizures; Electroencephalography (EEG); Hypoxic ischemic encephalopathy; Intracranial hemorrhage; Antiepileptic drugs; Phenobarbital; Neurodevelopmental outcome | ||
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