Benzimidazole Nucleus as a Privileged Scaffold in Medicinal Chemistry and its Therapeutic Applications | ||
| Egyptian Journal of Chemistry | ||
| Articles in Press, Accepted Manuscript, Available Online from 23 October 2025 | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/ejchem.2025.419604.12272 | ||
| Authors | ||
| Nada Gamal Aboshady* 1; Khaled Abouzid2; Yaseen A.M.M. ElShaier3; Mona S. El-Zoghbi4 | ||
| 1organic and medicinal chemistry department, faculty of pharmacy, university of sadat city, menofia. | ||
| 2Professor of pharmaceutical chemistry , Faculty of Pharmacy, University of Ain Shams,cairo, Egypt | ||
| 3Pharmaceutical and Organic Chemistry Department, Faculty of Pharmacy, University of Sadat City, Menoufia, Egypt. | ||
| 4Associate professor at Pharmaceutical Chemistry Department, Faculty of pharmacy, Menoufia University, Shibin ElKom, | ||
| Abstract | ||
| This review provides a comprehensive overview of benzimidazoles, a crucial class of heterocyclic compounds in medicinal chemistry, and the significant impact of drug repurposing. We highlight the historical importance and diverse biological activities of benzimidazoles, emphasizing their therapeutic applications across multiple fields. The review also explores Structure-Activity Relationship (SAR) studies, illustrating how specific substitutions on the core dictate activity in various therapeutic areas, such as anti-inflammatory, antihypertensive, anthelmintic, anti-ulcer and anticancer agents. The review heavily emphasizes drug repurposing strategy, highlighting its key benefits, classification, examples and challenges. It thoroughly examines successful cases where benzimidazole-based drugs, such as mebendazole, flubendazole, albendazole, and pimozide, have found new applications, especially in cancer treatment, metabolic and infectious diseases management. While acknowledging the inherent challenges, the review stresses drug repurposing's substantial promise for meeting unaddressed medical demands by broadening the uses of existing medications. | ||
| Keywords | ||
| Benzimidazole; SAR; anticancer; anthelmintic; drug repurposing, FDA-approved drugs | ||
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