Assessment of pediatric vascular thrombosis | ||
| Sohag Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 23 October 2025 | ||
| Document Type: Review Article | ||
| DOI: 10.21608/smj.2025.431899.1620 | ||
| Authors | ||
| Haidy Abdelazeem Youssef* 1; Alzahraa Elsayed Ahmed2; Eman Mohamed Fahmy3; Mohamed Kassem4 | ||
| 1Pediatric and neonatology department, faculty of medicine, sohag university, Sohag, Egypt | ||
| 2Department of Pediatrics, Faculty of Medicine, Sohag University, Sohag, Egypt. | ||
| 3Department of pediatric ,Faculty of Medicine, Sohag university. | ||
| 4Pediatric and neonatology department, faculty of medicine, Sohag university, Sohag, Egypt | ||
| Abstract | ||
| Background: Thrombosis is often underdiagnosed in neonates and toddlers. Thrombosis primarily occurs in the pediatric demographic prior to 1 year of age and during adolescence. Thrombosis is the abnormal formation of a clot from blood constituents within a vessel. It results from the disruption of the complex balance of the procoagulant, anticoagulant, and fibrinolytic systems. The morbidity and mortality rates are high, although it occurs less frequently than adult thrombosis and does not present without a triggering event. Objective: The aim of this review was to identify risk factors, clinical pattern, outcome of thrombosis in children Methods: A comprehensive search was conducted in PubMed, Google Scholar and Science Direct, from January 2000 to September 2025, using the key words: vascular thrombosis, arterial thrombosis, venous thrombosis, thrombophilia. The reviewers evaluated relevant literature references as well. Only the most recent or complete study was taken into account. Examples of articles that weren't regarded as significant scientific research include unpublished manuscripts, oral presentations, conference abstracts, and dissertations. The lack of resources for translation has led to the ignoring of documents written in languages other than English. Results: Both acquired and hereditary factors contribute to the development of thrombosis. The probability of thrombosis may increase in individuals with one or more hereditary thrombophilia factors. Acquired factors have been shown to induce thrombosis more frequently and effectively than inherited causes in pediatric cases. The principal factors influencing genetic predisposition to thrombophilia are the constituents of the coagulation cascade. | ||
| Keywords | ||
| Vascular thrombosis; arterial thrombosis; venous thrombosis; thrombophilia | ||
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