Toxicity and biochemical effects of lead, cadmium, acetamiprid and their mixtures on male mice | ||
| Journal of Pest Control and Environmental Sciences | ||
| Volume 6, Issue 1, June 1998, Pages 49-64 PDF (930.6 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jpces.1998.461437 | ||
| Authors | ||
| Deifalla H. Al-Rajhi; Fikry I. El-Shahawi* | ||
| Plant Protection Department, College of Apical, King Saud University, Riyadh, Saudi Arabia | ||
| Abstract | ||
| The toxicity and biochemical effects of feed (10 mg/kg/day), cadmium (I mg/kg/day), acetamiprid (34 & 68 mg/kg/day) and their mixtures after 4 days of oral administration on male white albino mice were investigated. Lead and cadmium treatments caused high percent mortalities 55.6% and 66.7 % respectively. While acetamiprid at 67.9 mg/kg/day caused 11.1 %-only. The mixtures of acetamiprid with lead and cadmium decreased the percent mortalities of lead and cadmium, this means that acetamiprid (cyanoimia group) had an aniagorismic effect to heavy metals. Furthermore, we studied the effect of lead and cadmium treatments on activity of @ALAD, ACHE and GST enzymes. Both caused significantly decrease of the activity of 8-ALAD: (52.12% & 19.94%), AChE (42.57% 28%) and GST (14.37% & 34.32%), while they caused elevation of serum LDH level (40% & 45.67%), respectively. On the other hand, the mixtures of acetamiprid with lead and cadmium decreased the inhibitory effect of lead and cadmium om &-ALAD & ACE activity and inhibited the elevation of serum LDH level. A correlation between toxicity and changes of enzymes activities as 2 results of lead, cadmium treatment and their mixtures with acetamiprid, was quite clear and demonstrated that acetamiprid may act as a protective agent against heavy metals intoxication. | ||
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