Thyroid Function in Healthy Preterm Infants at the NICU of Assiut University Children's Hospital: An Observational Study | ||
| Journal of Current Medical Research and Practice | ||
| Volume 10, Issue 4, October 2025, Pages 123-128 PDF (256.62 K) | ||
| Document Type: Original Article | ||
| Authors | ||
| Heba Ali* ; Hanaa Abdellateef Mohamad; Mohamed Gamil M.Aboelela | ||
| Pediatric, Faculty of Medicine, Assiut University, Assiut, Egypt, | ||
| Abstract | ||
| Introduction: Thyroid dysfunction is a common issue in preterm infants; physiological hypothyroxinemia is the most common thyroid function disorder in premature infants, followed by hypothyroidism from non-thyroidal causes. A number of conditions, including malnutrition, hypoxemia, acidosis, infections, hypoglycemia, and hypocalcemia, can slow the conversion of peripheral T4 to T3 in preterm. Objectives: Assess thyroid function in healthy preterm neonates on days 3–5 and 14. Patients and Methods: This observational study was done at the Neonatal Intensive Care Unit at Assiut University Children's Hospital, and included all preterm infants at the time of research, but those with any medical problems, fatal congenital malformations, or Children whose parents declined to take part in this research were not included. Anthropometric measurements, personal information, and those lab tests were recorded. Results: On days 3-5, three patients (6%) had hypothyroxinemia of prematurity, and four cases (8%) had hyperthyrotropinemia. On day 14, two cases (4%) and three cases (6%) had hypothyroxinemia of preterm and Hyperthyrotropinemia, respectively. Although there were more thyroid abnormalities overall on day 3 than on day 14, the difference was not statistically significant (p>0.05). Furthermore, a noteworthy correlation was observed between thyroid function, gestational age, and birth weight. Conclusion: Both birth weight and gestational age have an impact on thyroid dysfunction in preterm newborns. | ||
| Keywords | ||
| Preterm; Thyroid function; Hypothyroidism, Hypothyroxinemia | ||
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