The haematotoxicity of coumatetralyl and the antidotal effect of vitamin k in albino rats | ||
| Journal of Pest Control and Environmental Sciences | ||
| Volume 6, Issue 1, June 1998, Pages 89-100 PDF (723.28 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jpces.1998.461502 | ||
| Authors | ||
| Nagat M. Aly* 1; Rabeih K. AbuEl-Khear2; Nabila S. Ahmed3 | ||
| 1Agriculture Research Center, Sabahia, Alexandria | ||
| 2Agriculture Research Center, Etai El-Barod Beheera. | ||
| 3Faculty of Agriculture, Alexandria University, El-Shatby, Alexandria. | ||
| Abstract | ||
| The haematotoxicity of coumatetralyl, and the antidotal effect of vitamin K repeated doses on blood parameters was evaluated in albino rats anticoagulated with 1/2 LD50 of coumatetralyl. Anticoagulant administration resulted in hemorrhage accompanied by elevation in prothrombin time (PT) and partial thromboplastin time (PTT) and significant increases in white blood cells count (WBC's), while exhibited a significant reduction in haemoglobin content, haematocrit value, and red blood cells count (RBC's). The absolute values, the mean cell volume (MCV), the mean cell haemoglobin (MCH) and the mean cell haemogobin concentration (MCHC) represented macrocytic anew Vitamin K intake affected some haemotological parameters as reduction of PT and PTT to almost control. There is a significant dose related reduction in clotting time. While other parameters as haematocrit value, haemoglobin content, RBC's, WBC's and the absolute values did not normalize to control values. | ||
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