Teratogenic and biochemical effects of glyphosate on chick embryo | ||
| Journal of Pest Control and Environmental Sciences | ||
| Volume 6, Issue 2, December 1998, Pages 24-36 PDF (766.5 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jpces.1998.461515 | ||
| Authors | ||
| Sh. M. Awadallah1; N. Shaker2; K. A. Osman* 2 | ||
| 1The Mammalian Toxicology Lab. The Central Lab. of pesticides The Agric Res Center | ||
| 2Pesticides Chemistry Dept, Faculty of Agriculture, El Shatby, Alexandria University, Alexandria | ||
| Abstract | ||
| The herbicide glyphosate was tested for its teratogenic effects by injection of sublethal doses of 1D/10, LD50, LD50/100 and LD1000 in fertile eggs on day 6 of incubation. Body weight of fertile chicken eggs were recorded on 0, 6, 9, 12, 15 and 19 days. The fetuses on day 21 were examined. The results showed that mortality of fetuses was 100% for LD10 level, and decreased with the decrease of concentration. Similarly, the body weight of fetus and the abnormalities were dose dependent. Cases of opened abdomen, brain edema, eye enlargement, deficiency in feathers and appendages were recorded in eggs treated either with LD50/50 or LD50/100, while at LD 1000 level least abnormalities were observed. Acetylcholinesterase (AChE) and Alkaline phosphatase (ALP) activities were measured in brain and liver of chicks. The results indicated that AChE activity was inhibited, while ALP activity was stimulated in a dose dependent manner Finally, it can be concluded that both AChE and ALP enzymes can be used as biomarkers for exposure to glyphosate which can be harmful to humans and nontarget organisms | ||
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