Teratogenic effect of the fungicides benomyl and carbendazim on mice | ||
| Journal of Pest Control and Environmental Sciences | ||
| Volume 3, Issue 1, June 1991, Pages 143-153 PDF (1.21 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jpces.1991.461572 | ||
| Authors | ||
| A. A. Komeil* ; A. H. El-Sebae; M. A. Mohamed; O. M. Zorab | ||
| Chemistry of Pesticides Dept. College of Agriculture, University of Alexandria, Alexandria. Egypt | ||
| Abstract | ||
| Benomyl and Carbendazim are two plant systemic fungicides. The two compounds were administrated via the dietary route to pregnant Swiss albino female mice at dose of 250,500,100,1500 mg/Kg/day of each of the two compounds with or without corn oil from day 6 to day 17of gestation. The results showed that benomyl at 1500 mg/Kg/day and carbendazim at both 500 and 10000 g/Kg/day increased the number of resorbed fetuses. Besides carbendazim at 500 mg/Kg decrease the number of live fetuses. Skeletal malformations were shown in fetuses of both benomyl at 500 mg/Kg and carbendazim at 250 mg/Kg dose where leg and hand phalanges bones were absent. Benomyl at 1000 mg/Kg and carbendazim at 500 mg/Kg; the leg and hand phalanges were completely absent. While retarded ossification of partial and interparietal were induced. Parallel to theses malformation the placental alkaline phosphatase activity was diminished at the dose 1000 mg/Kg of benomyl and 500 mg/Kg of carbendazim. | ||
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