Toxicological studies with the anticoagulants, brodifacoum and difenacoum on mice | ||
| Journal of Pest Control and Environmental Sciences | ||
| Volume 3, Issue 2, December 1991, Pages 13-29 PDF (939.28 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jpces.1991.461576 | ||
| Author | ||
| Kawther S. El-Gendy* | ||
| Department of Pesticide Chemistry, Faculty of Agriculture, Alexandria University, Alexandria, Egypt. | ||
| Abstract | ||
| The effect of two dose levels of brodifacoum and difenacoum on some hematological and biochemical targets of male and female mice after 24 and 72 hours of treatments was studied. The data obtained showed that the red blood cells count (RBCs) decreased slightly in male and female mice treated with 1/4 LD50 of brodifacoum or difenacoum, while the higher dose (LD50) induced highly significant reduction. In contrast, the white blood cells count (WBC' s) increased. Also, the higher dose induced marked decreased in hemoglobin content (Hb) and hematocrit value (Hct). The prolongation in prothrombin time (PT) and partial thromboplastin time (PTT) was extended by increasing the dose level and reached their maximum values at the third day after treatment. The activity of liver aniline hydroxylase was significantly increased in treated mice. Brain adenosine triphosphatase (ATPase) increased after the same treatment, while liver ATPase was not changed significantly. Brodifacoum stimulated the activity of liver acid phosphatase (APase). Kidney APase slightly decreased in all treatments. Difenacoum did not induce a change in liver APase and glutamate oxaloacetate transaminase (GOT). The changes of the electrophoretic patterns of male mice plasma proteins treated with brodifacoum may be due to the dose levels or time elapsed after treatment; such changes were not markedly noticeable in female mice. | ||
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