Polymorphisms of IL-17A and IL-17F in Periodontal Disease: A Case Control Study
Abdelkawy, M., Tarrad, N., Shaker, O. (2019). Polymorphisms of IL-17A and IL-17F in Periodontal Disease: A Case Control Study. EKB Journal Management System, 3(1), 29-37. doi: https://doi.org/10.26810/perioj.2019.a4
Maha Abdelkawy; Nayroz Tarrad; Olfat Gamil Shaker. "Polymorphisms of IL-17A and IL-17F in Periodontal Disease: A Case Control Study". EKB Journal Management System, 3, 1, 2019, 29-37. doi: https://doi.org/10.26810/perioj.2019.a4
Abdelkawy, M., Tarrad, N., Shaker, O. (2019). 'Polymorphisms of IL-17A and IL-17F in Periodontal Disease: A Case Control Study', EKB Journal Management System, 3(1), pp. 29-37. doi: https://doi.org/10.26810/perioj.2019.a4
Abdelkawy, M., Tarrad, N., Shaker, O. Polymorphisms of IL-17A and IL-17F in Periodontal Disease: A Case Control Study. EKB Journal Management System, 2019; 3(1): 29-37. doi: https://doi.org/10.26810/perioj.2019.a4

Polymorphisms of IL-17A and IL-17F in Periodontal Disease: A Case Control Study

Perio J
Volume 3, Issue 1, July 2019, Pages 29-37    PDF (249.22 K)
Document Type: Original Article
DOI: https://doi.org/10.26810/perioj.2019.a4
Authors
Maha Abdelkawy* 1; Nayroz Tarrad2; Olfat Gamil Shaker3
1Department of Oral Diagnosis, Oral Medicine, and Periodontology, Faculty of Dentistry, Beni-Suef University, Beni-Suef, Egypt.
2Department of Oral Diagnosis, Oral Medicine, and Periodontology, Faculty of Dentistry, Fayoum University, Fayoum, Egypt.
3Department of Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt.
Abstract
Background: Increased interleukin-17 (IL-17) leads to the production of proinflammatory mediators and increases local inflammation. Interleukin-17 may also promote receptor activator of nuclear factor kappa-B ligand (RANKL) expression on gingival fibroblasts, T cells, and B cells, resulting in alveolar bone resorption. Interleukin-17A and IL-17F levels in saliva and gingival crevicular fluid (GCF), were found to be elevated in periodontitis patients. Thus, IL-17A and IL-17F polymorphisms were hypothesized to be associated with a risk of periodontitis. Methods: The present study was conducted on 60 subjects, including 20 stage II grade B periodontitis patients, 20 stage III grade C periodontitis patients, and 20 healthy controls. Blood samples were drawn from the subjects and analyzed for IL-17A G-197A and IL-17F 7488T/C genetic polymorphisms using the TaqMan assay. Results: There was a significant statistical difference between the distribution of the different genotypes and the different alleles in the three groups for IL-17A G-197A with the A allele presence indicating a risk of periodontitis. Conclusions: Interleukin-17A G-197A polymorphism is significantly associated with different clinical forms of periodontitis in the Egyptian population. The A allele could be considered a risk factor for periodontal diseases.
Keywords
Interleukin-17; single nucleotide polymorphisms; gene polymorphisms; periodontitis risk
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