Fabrication of a new cobalt(II) complex by a nitrogenous substituted pyridinone ligand and its antitumor profile
Sheliel, D., Ghaith, E., El-Ayaan, U., Nawar, N. (2025). Fabrication of a new cobalt(II) complex by a nitrogenous substituted pyridinone ligand and its antitumor profile. EKB Journal Management System, 68(5), 10-15. doi: 10.21608/mjcc.2025.431163.1035
Dina S. Sheliel; Eslam A. Ghaith; Usama El-Ayaan; Nagwa Nawar. "Fabrication of a new cobalt(II) complex by a nitrogenous substituted pyridinone ligand and its antitumor profile". EKB Journal Management System, 68, 5, 2025, 10-15. doi: 10.21608/mjcc.2025.431163.1035
Sheliel, D., Ghaith, E., El-Ayaan, U., Nawar, N. (2025). 'Fabrication of a new cobalt(II) complex by a nitrogenous substituted pyridinone ligand and its antitumor profile', EKB Journal Management System, 68(5), pp. 10-15. doi: 10.21608/mjcc.2025.431163.1035
Sheliel, D., Ghaith, E., El-Ayaan, U., Nawar, N. Fabrication of a new cobalt(II) complex by a nitrogenous substituted pyridinone ligand and its antitumor profile. EKB Journal Management System, 2025; 68(5): 10-15. doi: 10.21608/mjcc.2025.431163.1035

Fabrication of a new cobalt(II) complex by a nitrogenous substituted pyridinone ligand and its antitumor profile

Mansoura Journal of Chemistry
Volume 68, Issue 5, December 2025, Pages 10-15    PDF (1.35 M)
Document Type: Research Article
DOI: 10.21608/mjcc.2025.431163.1035
Authors
Dina S. Sheliel* 1; Eslam A. Ghaith2; Usama El-Ayaan1; Nagwa Nawar3
1Chemistry Department, Faculty of Science, Mansoura University, ET-35516-Mansoura, Egypt
2Chemistry Department, Faculty of Science, Mansoura University, ET-35516-Mansoura, Egypt Department of Chemistry, Faculty of Science, New Mansoura University, New Mansoura City, Egypt.
3Chemistry Department, Faculty of Science, Mansoura University, ET-35516-Mansoura, Egypt.
Abstract
Abstract: A new chelate of a nitrogenous substituted pyridinone ligand, designated as [Co(AHPO)(H2O)2(OAc)2].3H2O, has been prepared. The structural properties of this novel compound were completely characterized via a variety of methods, such as FT-IR, CHN analyses, and UV-visible spectroscopy. FTIR revealed that The AHPO ligand works as a neutral OO bidentate ligand chelating the Co(II) ion thru both the oxygen atoms of the carbonyl groups. Furthermore, magnetic and molar conductance were measured. The conductometric analysis of the isolated [Co(AHPO)(H2O)2(OAc)2].3H2O chelate exhibited negligible molar conductance affirming the non-electrolytic behavior of Co(II) complex and the existence of acetate anion inside the coordination sphere. Also, thermal TG and DTG methods were employed. Whereas Coats-Redfern and Horowitz-Metzger models were applied to evaluate the thermodynamic and kinetic parameters of the Co(II) complex. Eventually, the in vitro antitumor screening of the investigated [Co(AHPO)(H2O)2(OAc)2].3H2O complex was examined against two different cell lines. This encompassed liver cancer (HePG-2) and breast cancer (MCF-7).
Keywords
Pyridinone; Co(II) complex; Antitumor properties; Kinetic studies
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