Assessment of Serum Levels of Kisspeptin and Female Sex Hormones in Hypoactive Sexual Females Versus Sexual Healthy Females | ||
| Zagazig University Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 26 October 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2025.426518.4214 | ||
| Authors | ||
| Abdalla Hasan Kandil1; Dalia Atef Roshdy Hemead* 2; El sayed Mohammed Galal Khater3 | ||
| 1Professor of Dermatology, Venereology and Andrology Department, Faculty of Medicine - Zagazig University | ||
| 2Lecturer of physiology, Faculty of Medicine, Zagazig University, | ||
| 3Assistant Professor of Dermatology, Venereology and Andrology Department, Faculty of Medicine - Zagazig University | ||
| Abstract | ||
| Background: Hypoactive Sexual Desire Disorder (HSDD) is a prevalent form of female sexual dysfunction with a multifactorial pathophysiology involving hormonal, psychological, and neuroendocrine factors. Kisspeptin, a key neuropeptide in reproductive hormone regulation, has recently been implicated in sexual behavior and emotional processing. This study aimed to assess serum levels of kisspeptin, testosterone, estradiol, and prolactin in women with HSDD compared to healthy sexually active controls, and to evaluate their association with sexual function. Methods: A case-control study was conducted on 44 married women aged 20–50 years; 22 with HSDD and 22 healthy controls. Results: The HSDD group had a significantly lower mean FSFI score (20.6 ± 3.03) compared to controls (28.9 ± 1.3; p < 0.001), with all subdomains also significantly reduced (p < 0.001). Serum kisspeptin levels were markedly lower in HSDD cases (58.8 ± 5.4 ng/ml vs. 73.3 ± 4.7 ng/ml; p < 0.001), alongside reduced testosterone (0.08 ± 0.06 vs. 0.30 ± 0.1 ng/ml) and estradiol (66.9 ± 14.4 vs. 111.8 ± 16.7 pg/ml), and elevated prolactin (16.8 ± 4.7 vs. 9.01 ± 2 ng/ml; all p < 0.001). Kisspeptin correlated positively with FSFI total score (r = 0.791), desire (r = 0.785), testosterone (r = 0.719), and estradiol (r = 0.709), and negatively with prolactin (r = –0.678; all p < 0.001). Conclusion: Kisspeptin is significantly associated with sexual function and sex hormone levels in women. It may serve as a valuable biomarker and potential therapeutic target in the diagnosis and management of HSDD. | ||
| Keywords | ||
| Kisspeptin; Female Sex Hormones; Hypoactive Sexual Females | ||
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