Thiodicarb biotransformation to methomyl, toxicities and acetylcholinesterase inhibition in the land snail, Helix aspersa (Müller) | ||
| Journal of Pest Control and Environmental Sciences | ||
| Volume 7, Issue 2, June 1999, Pages 59-70 PDF (2.65 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jpces.1999.462103 | ||
| Authors | ||
| Mohamed A. Radwan* ; Ahmed K. Salama | ||
| Department of Pesticide Chemistry, Faculty of Agriculture, (El-Shatby) University of Alexandria, Alexandria, Egypt | ||
| Abstract | ||
| A high performance liquid chromatographic method confirmed with TLC was used to study the in vivo biotransformation of thiodicarb in the land snail, Helix aspersa (Muller). The toxicity and the in vivo acetylcholinesterase inhibition with thiodicarb and its major metabolite, methomyl were also investigated. The results showed that thiodicarb was quickly absorbed within 24 hrs following ingestion. The amount of thiodicarb reached a peak value of 198.60 ng/gm tissue at 3 days, and then rapidly declined as time passed to the end of experiment. Thiodicarb was rapidly metabolized to yield methomyl as a major metabolite in the snail tissues at all time intervals. Methomyl was found to be more toxic to the snails than thiodicarb. Results of the potency of both compounds against AChE activity were in harmony with their toxicities to snails. These results indicated that the formation of methomyl, in the snail, as a major metabolite explains the molluscicidal activity of thiodicarb. | ||
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