Dose-response analysis of acephate - induced developmental toxicity in mice | ||
| Journal of Pest Control and Environmental Sciences | ||
| Volume 7, Issue 3, December 1999, Pages 1-14 PDF (4.24 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jpces.1999.462108 | ||
| Authors | ||
| Amina T. Farag* 1; Mohamed I. Kamel2; M. H. Eweidah3 | ||
| 1Department of Pesticide Chemistry, Faculty of Agriculture, Alexandria University | ||
| 2Department of Community Medicine, Faculty of Medicine, Alexandria University, Egypt. | ||
| 3Department of Anatomy & Embryology "Faculty of Medicine, Alexandria University, Egypt. | ||
| Abstract | ||
| Acephate, an organophosphate insecticide, is evaluated to realize whether or not statistically significant increased response rates existed for the percentage of a particular endpoint of developmental toxicity parameters. The study involved four groups of 10 pregnant dams, one group serving as a control (distilled water) and the others exposed to various levels of acephate (7, 14, 28 mg/kg/day), by gavage, on gestation days 6 through 15. The outcomes of each pregnancy were recorded, and fetuses were examined for a variety of developmental defects. The Kruskal Wallis ANOVA was used in this study to test for a dose- response. The analysis revealed an overall statistically significant differences between all treated groups. While a significant increase in response rate in the reduction of the maternal weight gain occurred in 7 and 14 mg/kg/day treated groups at day 6 of gestation, there was no significant effects at day 15 of gestation. At day 18 of gestation, a significant increase in the percentage of dose-response in maternal weight gain of the group treated with the highest dose of acephate 28 mg/kg/day was noted. No effects were found in the response rates of heart and placenta weights compared to the control. However, the response rates of maternal liver, kidneys, brain, and spleen weights were significantly affected among all the treated groups compared to the control. Maternal exposure to acephate during organogenesis significantly affected the response rate of fetal weight, and induced an increase in response rates of external and skeletal malformations. On the basis of the present results acephate caused increase in response rates of developmental toxicity endpoints in all treated groups without dose-related pattern. | ||
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