SIRT1(rs7069102) Gene Polymorphism in Chronic Obstructive Pulmonary Disease in Egyptian Patients | ||
| Egyptian Journal of Medical Microbiology | ||
| Articles in Press, Accepted Manuscript, Available Online from 01 July 2026 PDF (352.36 K) | ||
| Document Type: New and original researches in the field of Microbiology. | ||
| DOI: 10.21608/ejmm.2025.431059.1922 | ||
| Authors | ||
| Zeinab M. Kadry1; Ebtisam M. Gad2; Noha S. Shafik* 3; Asmaa T. Mostafa4; Sara M. Sleim5; Alshimaa H. Abdelall1 | ||
| 1Department of Medical Biochemistry, Faculty of Medicine, Sohag University, Sohag, Egypt | ||
| 2Lecturer of Department of Chest diseases and Tuberculosis, Faculty of Medicine, Sohag University, Sohag, Egypt. | ||
| 3Medical Microbiology and Immunology, Faculty of Medicine, Sohag University | ||
| 4Clinical and Chemical pathology, Faculty of Medicine, Sohag University, Sohag, Egypt. | ||
| 5Otorhinolaryngology, department Faculty of Medicine, Sohag University, Sohag, Egypt. | ||
| Abstract | ||
| Background: Chronic obstructive pulmonary disease (COPD) is a prevalent condition characterized by shortness of breath, coughing, and sputum production. In Egypt, the prevalence is around 7.5%, with key risk factors including smoking and pollution. Objective: This study examined the association between the SIRT1 SNP (rs7069102) and CRP levels, and the roles of IL-26 and IL-10 in Egyptian COPD patients. Methodology: A case-control study involved 100 COPD patients and 100 healthy controls. Participants underwent assessments for BMI and spirometry, along with blood sampling for SIRT1 genotyping and measurement of IL-10 and IL-26. Results: The results highlighted reduced pulmonary function, elevated IL-26 levels, and lower IL-10 levels in COPD patients. Notably, serum IL-26 and IL-10 both demonstrated 100% sensitivity and specificity for diagnosing COPD at defined cutoffs. Conclusion: The SIRT1 (rs7069102) SNP may be a novel link to COPD, with patients showing a higher frequency of certain genotypes and altered cytokine levels. | ||
| Keywords | ||
| COPD; SIRT-1; IL-26; IL-10 | ||
|
Statistics Article View: 8 PDF Download: 6 |
||
