Cytotoxic activity of Frankincense volatile oil purified from Boswella serrate on Breast cancer cell line | ||
| Journal of Bioscience and Applied Research | ||
| Articles in Press, Accepted Manuscript, Available Online from 27 October 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jbaar.2025.397615.1234 | ||
| Authors | ||
| Ahmed Flayyih Hasan* 1; Ahmed F.Alshanon1; Mawj N. Modher1; Sarah M.Yaseen1; Omer Abid Kathum2; Khalil K. Ajeel1 | ||
| 1Biotechnology Research Center, Al-Nahrain University, Baghdad, Iraq. | ||
| 21Biotechnology Research Center, Al-Nahrain University, Baghdad, Iraq. | ||
| Abstract | ||
| Abstract Cancer is one of the main causes of mortality in the world. Various chemotherapeutic drugs are recognized to treat and manage this devastating disease through systemic drug discovery and development. This study aims to evaluate anti-cancer activity by frankincense oil volatile on the breast cancer (MCF-7). To achieve this goal, high content screening (HCS), antitumor measurement (MTT assay), which includes (nuclear density NI, number of viable cells VCC; membrane permeability MP; cytochrome C release and CMP cellular mitochondrial permeability), Caspase 9 detection. In this study displayed the capability of volatile oil to decrease the survival of tumor cells in a dose-dependent state within IC50 (116.9) compared to IC50 of (120.3) on normal cell line (HdFn) . Additionally, HCS results showed the ability of volatile oil to promote apoptosis of cancer cells. The pilot frankincense oil also activated the production of casabse 9 in a dose-dependent pattern and these effects caused by active compounds that possess anti-cancer activity against various cell lines such as MCF7. | ||
| Keywords | ||
| Keywords Frankincense; Boswella serrate; Apoptosis; Cytotoxicity; MCF-7 | ||
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