The impact of Hepatitis B Virus (HBV) infection in Some Hematologic Malignancies | ||
| Mansoura Journal of Biology | ||
| Volume 47, Issue 2, June 2020, Pages 48-57 PDF (1.16 M) | ||
| Document Type: Research Article | ||
| DOI: 10.21608/mjb.2020.462397 | ||
| Authors | ||
| Adel Ahmed EL- morsi* 1; Ashraf Abdel montaleb Al Sayed1; Doaa Abdalla Aladle2; Hamada Ali Zeina1 | ||
| 1Botany Department, Faculty of Science, Mansoura University | ||
| 2Department of clinical pathology, Faculty of Medicine, Mansoura University. | ||
| Abstract | ||
| Background: hepatitis B virus (HBV) is suspected to be an etiological agent, which increases the prevalence of hepatocellular carcinoma (HCC) in young non-cirrhotic cases. Recently, much research deal with the positive occurrence of stomach, liver, intrahepatic bile ducts, nasopharynx cancers and diffuse large B cell lymphoma (DLBCL) with H BV infection. Aim of the work: to estimate the existence of HBV and to clarify the role of HBV regulatory X Protein in subjects with lymphoma. Subject and Methods: this is a cross sectional study, which carried out on a cohort of 94 subjects with age range 16-50 years. The included subjects were divided into two groups. Group I (HBV negative subjects group): included 78 HBV negative subjects, which were approved by laboratory investigations. They were 39 females and 39 males; their mean age was 45.7 years with SD ±14.7. Group II (HBV positive subjects group): included 16 subjects with HBV positive. They were 9 females and 7 males; their mean of age was 52.5 years with SD ±10.2. RT-PCR and Elisa were used to detect HBV and HBx, respectively. Results: high prevalence of HBV was observed in older subjects' age. HBx protein concentration was increased in HBV +ve subjects group compared to HBV –ve subjects group, p value was <0.0001. HBx protein concentration was also increased in lymphoma cases compared to cases with reactive lymphadenopathy (P= 0.039). In addition, a significant increase of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and LDH activity were detected in the lymphoma subjects' group compared to non- lymphoma subjects' group, P value was 0.001, 0.001, and 0.04, respectively. Conclusion: HBV positive subjects have aggressive lymphoma. HBV infection could have a role in lymphoma development mainly Non Hodgkin lymphoma. It could be related to the HBx protein expression. Therefore, our study suggests that the early treatment of hepatitis virus infection mainly HBV could have an important role in decreasing malignancies development | ||
| Keywords | ||
| HBV; HBX protein; lymphoma | ||
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