Evaluation of Cardiac and Neurological Biomarkers as Predictors of Different Outcomes in Acute Carbon Monoxide Poisoning: A Prospective Study | ||
| Zagazig Journal of Forensic Medicine and Toxicology | ||
| Articles in Press, Accepted Manuscript, Available Online from 29 October 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zjfm.2025.416840.1227 | ||
| Authors | ||
| Gehan A. Ahmed1; Laila ME Sabik2; Aya A.F. Elgazzar2; Manar Ali Elsayed* 1 | ||
| 1Forensic Medicine and Clinical Toxicology Department, Faculty of Human Medicine, Zagazig University, Zagazig, Egypt | ||
| 2Forensic Medicine and Clinical Toxicology Department, Faculty of Human Medicine, Zagazig University, Zagazig, Egypt. | ||
| Abstract | ||
| Background: Cardiac and neurological insults induced by carbon monoxide (CO) poisoning are the main reasons for elevated mortality rates and morbidities. Accordingly, identifying high-risk patients is crucial. This work aims to enhance clinical management and predict outcomes in patients with CO poisoning. Subjects and Methods: A prospective cohort study, conducted at Zagazig University Hospital (ZUH) on 36 cases of acute CO poisoning, categorized according to their outcome into two groups: those with complications (7 cases) and those without complications (29 cases). Circulating biomarkers were measured for all participants. Results: The mortality rate was 8.3%. Approximately 80.6% recovered without complications. Carboxyhemoglobin (COHb), lactate, and malondialdehyde levels were significantly correlated with the outcome. Biomarker performance, as evaluated by receiver operating characteristic (ROC) curve analysis, showed that creatine kinase-MB (CK-MB) had an accuracy of 86.11% and an area under the curve (AUC) of 0.79. N-terminal pro-brain natriuretic peptide (NT-Pro BNP) demonstrated an accuracy of 77.78% and an AUC of 0.91, while troponin T exhibited an accuracy of 72.22% and an AUC of 0.81. In addition, creatine phosphokinase (CPK) had an accuracy of 97.22% and an AUC of 1, whereas neuron-specific enolase (NSE) showed an accuracy of 83.33% and an AUC of 0.89. The neutrophil lymphocyte ratio (NLR) had 77.78% accuracy, with an AUC of 0.82, similar to the glucose/potassium ratio (G/K ratio). Conclusions: CPK and NT-Pro BNP demonstrated excellent validity in predicting outcomes of CO poisoning. NSE, NLR, G/K ratio, and troponin T exhibited good validity, while CK-MB showed fair validity. | ||
| Keywords | ||
| Acute carbon monoxide toxicity; Cardiac and Neurological Biomarkers; NT-Pro BNP; Neuron Specific Enolase; Outcome Prediction; Mortality | ||
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