Evaluating the curative and protecting role of graviola leaf extract against hepatic and hematological disorders caused by monosodium glutamate in male rats | ||
| Mansoura Journal of Biology | ||
| Volume 45, Issue 4, December 2019, Pages 30-36 PDF (616 K) | ||
| Document Type: Research Article | ||
| DOI: 10.21608/mjb.2019.462678 | ||
| Authors | ||
| Wafaa M. EL-Kholy1; Mustafa Sh. Atta1; Walaa M. Nassar* 2 | ||
| 1Physiology Division, Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt | ||
| 2Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt | ||
| Abstract | ||
| The objective of the current study was to establish the curative and protective function of Graviola Leaf Extract versus MSG-produced hepatic groups, six for each as follows: Group 1(control): rats receiving distilled water; group 2 (G): and hematological disorders in Male Wistar Rats. Rats were haphazardly divided into five rats receiving G (200 mg / kg bw) regular oral administration for one month; group 3 (MSG): rats receiving MSG (100 mg / kg bw) daily oral administration for one month; group 4 (G+MSG): rats receiving G oral administration for one month and MSG for another month; group 5 (MSG+G): rats are given MSG orally for one month, followed by G for another month. Our results showed significant increases in body weight, TC, TG, LDL-C, AST, ALT, ALP, GGT, TB in serum as well as AST, ALT, ALP, GGT in liver tissue as well as major decreases in HDL-C, TP, Alb and improvement in CBC parameters such as (RBCs, Hb, Hct percent, MCH, MCV, WBCs). On the other hand, G administration significantly improved the deviation resulting from MSG in all parameters and marked CBC development. Ultimately, it could be concluded that to reduce the hepatic and hematological from damage caused by MSG and G should be taken before MSG as a protective agent . | ||
| Keywords | ||
| Graviola; MSG; Hepatotoxicity; Hematological parameters | ||
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