Prophylactic effect of date fruit extract on hepatotoxicity induced by either carbon tetrachloride or diethylnitrosamine in male rats | ||
| Mansoura Journal of Biology | ||
| Volume 44, Issue 3, September 2019, Pages 39-54 PDF (843.67 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjb.2019.462693 | ||
| Authors | ||
| Faried A. E. Hemieda* ; Mamdouh R. F. El-Sawi; Doaa M. M. Assasa | ||
| Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt | ||
| Abstract | ||
| The aim of this research was to explore the protective effect of date palm fruit extract (DFE) on either carbon tetrachloride (CCl4)- or diethylnitrosamine (DENA)-induced hepatotoxicity in male albino rats. CCl4 and DENA were given in a single intraperitoneal (ip) dose of 3ml/kg and 150 mg/kg, respectively. Rats injected with CCl4 or DENA showed significant increases in the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin (TB), total protein (TP) and albumin (ALB). Moreover, there were a significant elevation in the hepatic content of malondialdehyde (MDA); and a significant inhibition in both the level of reduced glutathione (GSH) and the activities of antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione-s-transferase(GST)in the liver of the intoxicated rats. On the other hand, the results exhibited marked enhancement in the concentrations of total lipids (TL), total cholesterol (TC), triglycerides (TG) and low density lipoprotein-cholesterol (LDL-C); while the level of high density lipoprotein-cholesterol (HDL-C) was significantly decreased in CCl4- or DENA-treated rats. Pretreatment with DFE (1g/kg) for 4 weeks to rats injected with a single dose of either CCl4 (3ml/kg) or DENA (150 mg/kg) significantly alleviated the toxin-induced detrimental effects in the above mentioned biochemical parameters. Finally, it could be concluded that DFE is a hepatoprotective agent and can be protect against either CCl4- or DENA-induced hepatotoxicity in rats | ||
| Keywords | ||
| Hepatotoxicity; Carbon tetrachloride; Diethylnitrosamine; Date palm fruit extract; Antioxidant enzymes | ||
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